{"doi":"10.1117/1.nph.9.3.035004","title":"Comparison of optical measurements of critical closing pressure acquired before and during induced ventricular arrhythmia in adults","abstract":"Significance: The critical closing pressure (CrCP) of cerebral circulation, as measured by diffuse correlation spectroscopy (DCS), is a promising biomarker of intracranial hypertension. However, CrCP techniques using DCS have not been assessed in gold standard experiments.Aim: CrCP is typically calculated by examining the variation of cerebral blood flow (CBF) during the cardiac cycle (with normal sinus rhythm). We compare this typical CrCP measurement with a gold standard obtained during the drops in arterial blood pressure (ABP) caused by rapid ventricular pacing (RVP) in patients undergoing invasive electrophysiologic procedures.Approach: Adults receiving electrophysiology procedures with planned ablation were enrolled for DCS CBF monitoring. CrCP was calculated from CBF and ABP data by three methods: (1) linear extrapolation of data during RVP (CrCPRVP; the gold standard); (2) linear extrapolation of data during regular heartbeats (CrCPLinear); and (3) fundamental harmonic Fourier filtering of data during regular heartbeats (CrCPFourier).Results: CBF monitoring was performed prior to and during 55 episodes of RVP in five adults. CrCPRVP and CrCPFourier demonstrated agreement (R = 0.66, slope = 1.05 (95%CI, 0.72 to 1.38). Agreement between CrCPRVP and CrCPLinear was worse; CrCPLinear was 8.2 ± 5.9 mmHg higher than CrCPRVP (mean ± SD; p < 0.001).Conclusions: Our results suggest that DCS-measured CrCP can be accurately acquired during normal sinus rhythm.","journal":"Neurophotonics","year":2022,"id":274334,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":709798,"name":"Elizabeth Mahanna","orcid":"0000-0002-1297-1432","position":1,"is_corresponding":false},{"id":302191,"name":"Karla M. Bergonzi","orcid":"0000-0002-1459-2882","position":2,"is_corresponding":false},{"id":942384,"name":"Rodrigo M. Forti","orcid":"0000-0002-8978-2525","position":3,"is_corresponding":false},{"id":343795,"name":"Tiffany S. Ko","orcid":"0000-0002-5113-0310","position":4,"is_corresponding":false},{"id":942823,"name":"Ronak M. Shah","orcid":null,"position":5,"is_corresponding":false},{"id":316427,"name":"Jeffrey Arkles","orcid":"0000-0002-4928-3887","position":6,"is_corresponding":false},{"id":343801,"name":"Daniel J. Licht","orcid":"0000-0002-4080-843X","position":7,"is_corresponding":false},{"id":313769,"name":"Arjun G. Yodh","orcid":"0000-0003-4744-2706","position":8,"is_corresponding":false},{"id":683376,"name":"W. Andrew Kofke","orcid":"0000-0003-0718-3834","position":9,"is_corresponding":false},{"id":698054,"name":"Brian R. White","orcid":"0000-0001-5196-2339","position":10,"is_corresponding":false},{"id":656993,"name":"Wesley B. Baker","orcid":"0000-0002-3025-6061","position":11,"is_corresponding":false},{"id":942383,"name":"Alec Lafontant","orcid":"0000-0003-3669-0114","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T00:28:07.776043Z","pmid":"36039170","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}