{"doi":"10.1117/1.nph.6.2.025011","title":"Functional near-infrared spectroscopy-informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility","abstract":null,"journal":"Neurophotonics","year":2019,"id":650037,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":365809,"name":"Yihan Jiang","orcid":"0000-0001-9169-1529","position":1,"is_corresponding":false},{"id":1694827,"name":"Yilong Gong","orcid":null,"position":2,"is_corresponding":false},{"id":1341675,"name":"Weihua Zhao","orcid":"0000-0003-1681-7368","position":3,"is_corresponding":false},{"id":975904,"name":"Zhiying Zhao","orcid":"0000-0002-0369-1308","position":4,"is_corresponding":false},{"id":1330189,"name":"Xiaolong Liu","orcid":"0000-0002-3814-5606","position":5,"is_corresponding":false},{"id":1571256,"name":"Keith M. Kendrick","orcid":"0000-0002-0371-5904","position":6,"is_corresponding":false},{"id":364828,"name":"Chaozhe Zhu","orcid":"0000-0002-9247-9607","position":7,"is_corresponding":false},{"id":818183,"name":"Benjamin Becker","orcid":"0000-0002-9014-9671","position":8,"is_corresponding":false},{"id":1592969,"name":"Keshuang Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Functional near-infrared spectroscopy-informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility","abstract":"Cognitive flexibility and reward processing critically rely on the orbitofrontal cortex (OFC). Dysregulations in these domains and orbitofrontal activation have been reported in major psychiatric disorders. Hemodynamic brain imaging-informed neurofeedback allows regional-specific control over brain activation and thus may represent an innovative intervention to regulate orbitofrontal dysfunctions. Against this background the present proof-of-concept study evaluates the feasibility and behavioral relevance of functional near-infrared spectroscopy (fNIRS)-assisted neurofeedback training of the lateral orbitofrontal cortex (lOFC). In a randomized sham-controlled between-subject design, 60 healthy participants have undergone four subsequent runs of training to enhance the lOFC activation. Training-induced changes in the lOFC, attentional set-shifting performance, and reward experience have served as primary outcomes. Feedback from the target channel significantly increases the regional-specific lOFC activation over the four training runs in comparison with sham neurofeedback. The real-time OFC neurofeedback group demonstrates a trend for faster responses during the set-shifting relative to the sham neurofeedback group. Within the real-time OFC neurofeedback group, stronger training-induced lOFC increases are associated with higher reward experience. The present results demonstrate that fNIRS-informed neurofeedback allows regional-specific regulation of lOFC activation and may have the potential to modulate the associated behavioral domains. As such fNIRS-informed neurofeedback may represent a promising strategy to regulate OFC dysfunctions in psychiatric disorders.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31930153","pmcid":"PMC6951484","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"91632117","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31530032","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"61431002","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.spiedigitallibrary.org/journals/Neurophotonics/volume-6/issue-2/025011/Functional-near-infrared-spectroscopy-informed-neurofeedback--regional-specific-modulation/10.1117/1.NPh.6.2.025011.pdf","host_type":"publisher"},{"url":"https://www.spiedigitallibrary.org/journalArticle/Download?urlId=10.1117%2F1.NPh.6.2.025011","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6951484","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6951484","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6951484?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Neurofeedback","Reward","Neuromodulation","Orbitofrontal Cortex","Cognitive Flexibility","Functional Near-infrared Spectroscopy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:44:39.272314Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}