{"doi":"10.1117/1.jbo.29.1.016003","title":"Improved intraoperative identification of close margins in oral squamous cell carcinoma resections using a dual aperture fluorescence ratio approach: first in-human results","abstract":"Significance: around the excised tumor) is the goal as it results in reduced local recurrence rates and improved overall survival. Aim: ), they have had limited success in the detection of \"close\" inadequate margins (1 to 5 mm). Here, a dual aperture fluorescence ratio (dAFR) approach was evaluated as a means of improving detection of close margins. Approach: The approach was evaluated on surgical specimens from patients who were administered a tumor-specific fluorescent imaging agent (cetuximab-800CW) prior to surgery. The dAFR approach was compared directly against standard wide-field fluorescence imaging and pathology measurements of margin thickness in specimens from three patients and a total of 12 margin locations (1 positive, 5 close, and 6 clear margins). Results: ). Conclusions: These results provide evidence that the dAFR approach potentially improves detection of close surgical margins.","journal":"Journal of Biomedical Optics","year":2024,"id":463050,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1293332,"name":"Jaron G. de Wit","orcid":"0000-0002-0097-429X","position":1,"is_corresponding":false},{"id":1293333,"name":"Jasper Vonk","orcid":"0000-0003-1620-5505","position":2,"is_corresponding":false},{"id":1293647,"name":"Jennifer Vorjohan","orcid":null,"position":3,"is_corresponding":false},{"id":1293648,"name":"Sophia Nelson","orcid":null,"position":4,"is_corresponding":false},{"id":1293649,"name":"Allyson Trang","orcid":null,"position":5,"is_corresponding":false},{"id":1174957,"name":"Brooke Villinski","orcid":null,"position":6,"is_corresponding":false},{"id":377168,"name":"Kimberley S. Samkoe","orcid":"0000-0002-8234-2308","position":7,"is_corresponding":false},{"id":1143592,"name":"Jovan G. Brankov","orcid":"0000-0001-6398-4711","position":8,"is_corresponding":false},{"id":480581,"name":"Floris J. Voskuil","orcid":"0000-0003-3740-4554","position":9,"is_corresponding":false},{"id":480586,"name":"Max J. H. Witjes","orcid":"0000-0002-4135-3246","position":10,"is_corresponding":false},{"id":511976,"name":"Kenneth M. Tichauer","orcid":"0000-0003-1667-3026","position":11,"is_corresponding":false},{"id":1143589,"name":"Cody C. Rounds","orcid":"0009-0003-2586-2731","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:04:28.838123Z","pmid":"38235321","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}