{"doi":"10.1117/1.jbo.27.1.016003","title":"In vivo safety study using radiation at wavelengths and dosages relevant to intravascular imaging","abstract":"SIGNIFICANCE: Intravascular photoacoustic (IVPA) imaging can identify native lipid in atherosclerotic plaques in vivo. However, the large number of laser pulses required to produce 3D images is a safety concern that has not been fully addressed. AIM: We aim to evaluate if irradiation at wavelengths and dosages relevant to IVPA imaging causes target vessel damage. APPROACH: We irradiate the carotid artery of swine at one of several energy dosages using radiation at 1064 or 1720 nm and use histological evaluation by a pathologist to identify dose-dependent damage. RESULTS: Media necrosis was the only dose-dependent form of injury. Damage was present at a cumulative fluence of 50 J / cm2 when using 1720 nm light. Damage was more equivocally identified at 700 J / cm2 using 1064 nm. CONCLUSIONS: In prior work, IVPA imaging of native lipid in swine has been successfully conducted below the damage thresholds identified. This indicates that it will be possible to use IVPA imaging in a clinical setting without damaging vessel tissue. Future work should determine if irradiation causes an increase in blood thrombogenicity and confirm whether damaged tissue will heal over longer time points.","journal":"Journal of Biomedical Optics","year":2022,"id":289756,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9663,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":454152,"name":"Don VanderLaan","orcid":null,"position":1,"is_corresponding":false},{"id":971822,"name":"Andrei Karpiouk","orcid":null,"position":2,"is_corresponding":false},{"id":742097,"name":"Daisuke Onohara","orcid":"0000-0002-2101-9865","position":3,"is_corresponding":false},{"id":971823,"name":"Susan Schmarkey","orcid":null,"position":4,"is_corresponding":false},{"id":971824,"name":"Serge Rousselle","orcid":null,"position":5,"is_corresponding":false},{"id":526788,"name":"Muralidhar Padala","orcid":"0000-0003-4304-2449","position":6,"is_corresponding":false},{"id":382933,"name":"Stanislav Emelianov","orcid":"0000-0002-7098-133X","position":7,"is_corresponding":false},{"id":404846,"name":"Timothy Sowers","orcid":"0000-0001-9293-0472","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:30:22.686776Z","pmid":"35102728","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}