{"doi":"10.1117/1.ap.2.6.065002","title":"High spatial and temporal resolution synthetic aperture phase microscopy","abstract":"A new optical microscopy technique, termed high spatial and temporal resolution synthetic aperture phase microscopy (HISTR-SAPM), is proposed to improve the lateral resolution of wide-field coherent imaging. Under plane wave illumination, the resolution is increased by twofold to around 260 nm, while achieving millisecond-level temporal resolution. In HISTR-SAPM, digital micromirror devices are used to actively change the sample illumination beam angle at high speed with high stability. An off-axis interferometer is used to measure the sample scattered complex fields, which are then processed to reconstruct high-resolution phase images. Using HISTR-SAPM, we are able to map the height profiles of subwavelength photonic structures and resolve the period structures that have 198 nm linewidth and 132 nm gap (i.e., a full pitch of 330 nm). As the reconstruction averages out laser speckle noise while maintaining high temporal resolution, HISTR-SAPM further enables imaging and quantification of nanoscale dynamics of live cells, such as red blood cell membrane fluctuations and subcellular structure dynamics within nucleated cells. We envision that HISTR-SAPM will broadly benefit research in material science and biology.","journal":"Advanced Photonics","year":2020,"id":65019,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":343965,"name":"Di Jin","orcid":"0000-0002-9587-1698","position":1,"is_corresponding":false},{"id":343966,"name":"Yanping He","orcid":"0000-0002-7019-4627","position":2,"is_corresponding":false},{"id":343967,"name":"Hongtao Lin","orcid":"0000-0001-7432-3644","position":3,"is_corresponding":false},{"id":343968,"name":"Juejun Hu","orcid":"0000-0002-7233-3918","position":4,"is_corresponding":false},{"id":343969,"name":"Zahid Yaqoob","orcid":"0000-0003-2487-9497","position":5,"is_corresponding":false},{"id":79847,"name":"Peter T. C. So","orcid":"0000-0003-4698-6488","position":6,"is_corresponding":false},{"id":343970,"name":"Renjie Zhou","orcid":"0000-0002-4761-6641","position":7,"is_corresponding":false},{"id":343964,"name":"Cheng Zheng","orcid":"0009-0001-0367-8701","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:13:23.327603Z","pmid":"33870104","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}