{"doi":"10.1115/dmd2025-1075","title":"Proof of Concept for a Device to Standardize Cellular Migration Assay Experiments","abstract":"One of the most common techniques for investigating the migration of human cells in culture is a \"scratch assay\" where a pipette tip is dragged through a layer of cells creating a \"wound\". Migration is then observed as the cells move back into the area that was cleared. While common, this method has drawbacks. It requires a seasoned hand to perform the \"scratch\", it leaves behind wounded remains of cells creating a unique microenvironment, and by design, the scratch is jagged and ununiform in nature. This research demonstrates the functionality of a cheap, easy to implement 3D printed device that mimics this assay. Its benefits include needing virtually no training to use, creating uniform areas for migration, and limiting cell death.","journal":"PubMed","year":2025,"id":567480,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1471527,"name":"Ghoulem Ifrene","orcid":"0000-0003-4277-7179","position":1,"is_corresponding":false},{"id":1009845,"name":"Amanda Haage","orcid":"0000-0001-6305-440X","position":2,"is_corresponding":false},{"id":1471845,"name":"Aiyana Montclair","orcid":null,"position":3,"is_corresponding":false},{"id":1471844,"name":"Nicholas Bittner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":4,"raw_metadata":null,"created_at":"2026-07-19T02:56:44.340853Z","pmid":"41788863","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}