{"doi":"10.1113/jp287608","title":"Chloride channels in endothelial cells","abstract":"Abstract Endothelial cells (ECs) line the lumen of blood and lymphatic vessels and form capillaries. ECs are exposed to a diverse array of physiological stimuli and regulate a multitude of functions, including contractility, blood coagulation, leukocyte recruitment, wound healing, angiogenesis and the blood–tissue exchange of gases, metabolites and macromolecules. Chloride (Cl − ) is the principal anion in ECs, with its intracellular concentration ([Cl − ] i ) regulated by pumps, transporters and channels. ECs express the Cl − channel proteins transmembrane protein 16A (TMEM16A, ANO1), leucine‐rich repeat (LRR)‐containing 8 (LRRC8), CLCs and cystic fibrosis transmembrane conductance regulator (CFTR), which are plasma membrane proteins, and CLICs, which are located on intracellular organelles. Cl − channels can regulate both the membrane potential and [Cl − ] i of ECs to modulate physiological functions. Recent evidence indicates that intracellular Cl − is a physiological second messenger that regulates the activity of WNK (i.e. with‐no‐lysine) kinases in ECs. Impaired functions of Cl – channels in ECs have also been associated with diseases such as hypertension, atherosclerosis, cancer and lung oedema. This review discusses the current knowledge of individual Cl − channel types that are expressed in ECs, as well as their signalling mechanisms, physiological functions and pathological relevance. image","journal":"The Journal of Physiology","year":2025,"id":522175,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":917739,"name":"Tessa A. C. Garrud","orcid":"0000-0002-7900-7939","position":1,"is_corresponding":false},{"id":353069,"name":"Jonathan H. Jaggar","orcid":"0000-0003-1505-3335","position":2,"is_corresponding":false},{"id":353065,"name":"Alejandro Mata‐Daboin","orcid":"0000-0003-1831-7842","position":0,"is_corresponding":true}],"reference_count":190,"raw_metadata":null,"created_at":"2026-07-19T02:49:49.198144Z","pmid":"41054230","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}