{"doi":"10.1113/jp284979","title":"Cell diversity and signalling in the cardiovascular system","abstract":"The special issue of The Journal of Physiology entitled ‘Cell diversity and signalling in the cardiovascular system’ is the outcome of the 7th UC Davis Cardiovascular Symposium, which was held on 25 and 26 March 2022 and brought together leading experts from around the world to share their insights on this important and rapidly evolving area of research. The symposium highlighted the critical role of cellular diversity in maintaining cardiovascular health, and the need to understand the complex interplay between cells and their signalling pathways in both health and disease. The special issue includes a white paper, a review and six original research papers, as well as corresponding perspective articles providing expert commentary and analysis of the latest exciting findings in this important field. The white paper in this special issue provides a comprehensive overview of the state of the art in cell diversity research, highlighting key findings and identifying areas where more work is needed (Grandi et al., 2023). The article examines the role of myocytes and non-myocyte cells in the heart and in the vasculature and how they interact with other cell types to maintain normal heart function. A perspective article (Kass, 2023) highlights the significance of the white paper in surveying the key cell types and signalling pathways involved in cardiovascular function, the complexity that exists at the subcellular, cellular and system levels, and the importance of technological advancements that enable the exploration of this diversity, which ultimately enhances our understanding of integrated cardiovascular function and dysfunction. As such, the white paper serves as a resource not only for investigators in the field of cardiovascular physiology but also for those seeking relevant references for reviewing the state of the art in this field, regardless of their area of specialization (Kass, 2023). The topical review by Salameh et al. (2023) delves into the developmental progression of the human heart, with a specific emphasis on its structure, electrophysiology, metabolic profile and contractile function. While making helpful comparisons with animal models of cardiac development, the article primarily focuses on human tissue samples, and thus offers a unique perspective and a detailed exploration of the field. The authors identify the limited number of publications from human tissue samples as a major limitation, highlighting the need for more comprehensive studies to better understand paediatric cardiomyocyte physiology. These studies are essential to expand our knowledge of normal cardiac physiology and pathophysiology and will help to improve clinical care by guiding the development of age-appropriate treatment strategies for cardiac disease (Salameh et al., 2023). The six original research papers in this special issue tackle a wide range of topics related to cell diversity in the cardiovascular system, from the identification and characterization of novel interactions of signalling pathways and cell types in cardiovascular disease and arrhythmia to the role of subcellular and ionic processes in modulating cardiovascular responses to stressors. These papers provide insights into the complex and multiscale landscape of the heart and blood vessels, shedding light on the mechanisms underlying both physiological and pathological processes. Chowkwale et al. (2023) introduce a computational framework that enables the modelling of cellular dynamics and immune cell–fibroblast interactions in the context of myocardial infarction. Through calibration and validation against existing datasets from mice, the model successfully predicts several critical biological parameters related to cardiac wound healing, such as cytokine secretion, phagocytosis and cell content. Moreover, the framework is utilized to investigate the factors that contribute to inflammation onset and resolution. Model predictions establish a novel concept of inflammation–fib","journal":"The Journal of Physiology","year":2023,"id":407509,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9367,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471958,"name":"Eleonora Grandi","orcid":"0000-0002-4401-8857","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T01:21:10.867368Z","pmid":"37211722","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}