{"doi":"10.1113/jp279590","title":"Variability in hypoxic response: Could genetics play a role?","abstract":"The biological response to hypoxia leads to important fundamental questions regarding health and disease. Some patients exposed to hypoxia develop a waxing and waning breathing pattern known as periodic breathing (PB). Similarly, patients with congestive heart failure can develop Cheyne Stokes breathing (CSB), which has been somewhat controversial as a result of uncertainty about its prognostic impact and its optimal therapy (Bradley et al. 2005). In this issue of The Journal of Physiology, the new findings reported by Lancaster et al. (2020) not only shed new light on these issues, but also raise broader questions about genetic susceptibility to various breathing patterns and their associated consequences. In terms of control of breathing, loop gain is an engineering term that has been used to quantify the stability or instability of a negative feedback control system. A system with a high loop gain is one prone to instability, whereas a system with low loop gain is intrinsically stable (Khoo, 2000). The loop gain of the ventilatory control system is a function of factors including the controller (i.e. chemoresponsiveness), as well as a plant (based on the efficiency of CO2 excretion). Hypoxia can contribute to instability depending on the hypoxic ventilatory response, which may vary based on genetic and other factors. Elevated loop gain is important clinically (e.g. CSB and PB at high altitude) because it may be amenable to oxygen therapy or acetazolamide. Some cases may respond to new forms of non-invasive ventilation, such as adaptive or auto servoventilation (ASV), although outcome data are mixed. Elevated loop gain has also been associated with failure of upper airway surgery for obstructive sleep apnea (OSA) and the development of central apnea for OSA patients when given continuous positive airway pressure. Based on the crescendo-decrescendo breathing pattern in CSB, patients can experience hypoxia with reoxygenation leading to oxidative stress, recurrent arousals from sleep during periods of hyperpnea, and repetitive surges in catecholamines in response to pathophysiological stimuli. Thus, CSB complications may involve many pathways, including autonomic, inflammatory and oxidative stress mediated. Given the variable prognosis of CSB and the inconsistent results of therapeutic studies to eliminate CSB, there is probably individual variability in the occurrence of CSB and in its haemodynamic and neurocognitive consequences (Heinrich et al. 2019). Lancaster et al. (2020) report possible associations with oxidative stress genes, which, in theory, could determine which patient may be susceptible to CSB. In particular, the selected anti-oxidative genes play a role in defence against oxidative stress, and the NOTCH signalling pathway interacts with hypoxia sensing pathways and plays an important role in neurodevelopment. The candidate-gene approach has been debated given the availability of genomics information (e.g. from genome-wide association studies) within the past decade, and a push to utilize knowledge from publicly available databases and in silico tools is warranted in such studies. Of note, we and others have prioritized candidate genes that may be important in mediating the biological response to hypoxia based on extensive genome analysis and known gene function. For example, EGLN1 and EPAS1 play an important role in determining the variability in response to hypobaric hypoxia at altitude (Simonson et al. 2010) and have been linked to the development of polycythemia and associated abnormalities. However, we are unclear as to how Lancaster et al. (2020) determined their candidate genes of interest given that the general categories mentioned encompass many potentially relevant genes, and we encourage further development in this area in such studies. As with all exciting research, the new findings raise a number of questions for the scientist. First, are there other candidate genes which may be important in modulatin","journal":"The Journal of Physiology","year":2020,"id":106239,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270458,"name":"Atul Malhotra","orcid":"0000-0002-9509-1827","position":1,"is_corresponding":false},{"id":341457,"name":"Tatum S. Simonson","orcid":"0000-0003-4062-2587","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-18T23:12:27.124515Z","pmid":"32281106","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}