{"doi":"10.1113/ep092018","title":"Chronic intermittent hypoxia‐mediated cognitive dysfunction in ovariectomized rats","abstract":"Obstructive sleep apnoea (OSA) is a prevalent cardiorespiratory disorder associated with significant neurocognitive consequences. Despite the higher prevalence of OSA in men, there is a strong association between OSA and Alzheimer's disease (AD), which disproportionately affects women. This study aimed to investigate the impact of chronic intermittent hypoxia (CIH), a hallmark of OSA, on cognitive function and AD markers in ovariectomized, female rats. At 8 weeks of age, 16 Sprague-Dawley rats underwent ovariectomy and were exposed to CIH for 26 weeks. Cognitive function was assessed using the Morris water maze, revealing significant deficits in spatial learning (P < 0.0001) and memory (P = 0.008) in CIH-exposed rats, compared to controls. Analysis of hippocampal tissue showed increased total tau protein (P = 0.0078), indicative of AD pathology. Additionally, CIH-exposed rats exhibited respiratory dysfunction characterized by increased frequency of apnoeas (P = 0.0328). These findings provide preclinical evidence of the association between OSA, cognitive decline and AD pathology in females, emphasizing the importance of sex-specific research in understanding and addressing these pathophysiological interconnections.","journal":"Experimental Physiology","year":2025,"id":521217,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9628,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":413060,"name":"Joan B. Escobar","orcid":null,"position":1,"is_corresponding":false},{"id":901434,"name":"Bridget R. Alber","orcid":null,"position":2,"is_corresponding":false},{"id":1050801,"name":"Caitlin Ribeiro","orcid":"0000-0003-2935-6046","position":3,"is_corresponding":false},{"id":1392066,"name":"Ishan Abdullah","orcid":null,"position":4,"is_corresponding":false},{"id":1009815,"name":"Grant Kowalik","orcid":"0000-0003-4862-5299","position":5,"is_corresponding":false},{"id":412354,"name":"Jeannette Rodriguez","orcid":"0000-0001-7791-5266","position":6,"is_corresponding":false},{"id":1068294,"name":"Grey Harral","orcid":null,"position":7,"is_corresponding":false},{"id":1068295,"name":"Makeda Melkie","orcid":null,"position":8,"is_corresponding":false},{"id":1067871,"name":"Aman S. Gill","orcid":"0000-0003-0296-5845","position":9,"is_corresponding":false},{"id":1121958,"name":"John T. Ketzenberger","orcid":null,"position":10,"is_corresponding":false},{"id":514998,"name":"John R. Bethea","orcid":"0000-0003-2078-5565","position":11,"is_corresponding":false},{"id":266238,"name":"Vsevolod Y. Polotsky","orcid":"0000-0002-2951-7535","position":12,"is_corresponding":false},{"id":450928,"name":"Vivek Jain","orcid":"0000-0001-8879-6506","position":13,"is_corresponding":false},{"id":471703,"name":"Kathryn J. Schunke","orcid":"0000-0002-0815-8457","position":14,"is_corresponding":false},{"id":404156,"name":"Matthew W. Kay","orcid":"0000-0003-2756-5055","position":15,"is_corresponding":false},{"id":317053,"name":"David Mendelowitz","orcid":"0000-0001-7107-1832","position":16,"is_corresponding":false},{"id":782904,"name":"Emily C. Cheung","orcid":"0000-0002-7642-2950","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:49:44.558743Z","pmid":"40388406","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}