{"doi":"10.1111/xen.70013","title":"Transplant Patients’ Perceptions About Participating in First‐in‐Human Pig Kidney Xenotransplant Clinical Trials: A Mixed Methods Study","abstract":"First-in-human pig xenotransplant clinical trials may soon begin, which raises ethical concerns about patients' decision-making to participate in such trials. We assessed kidney transplant candidates' attitudes and hypothetical decision-making about participating in xenotransplant trials through semi-structured telephone interviews and an online survey. We analyzed qualitative data by thematic analysis and quantitative data by descriptive statistics. Twenty-eight patients participated in interviews; 142 patients participated in the survey. Most interview and survey respondents were male (68%, 56%), White (54%, 61%), or Black (36%, 22%). Although interview participants appreciated xenotransplantation research's potential to advance science, they expressed concerns about infection transmission and graft function. Few survey respondents were willing to participate in a pig kidney trial to test the safety of pig kidneys (12.6%) or pig kidney function (16.9%). Interview participants would be more likely to participate in a first-in-human pig kidney trial if receiving a human kidney was unlikely and their health status declined. Willingness would also depend on how long the pig kidney would function. Most interview participants were receptive to long-term monitoring, but not to family monitoring. Transplant programs planning xenotransplant trials should anticipate these types of concerns for optimizing human subject protections and conducting a robust informed consent process.","journal":"Xenotransplantation","year":2025,"id":529740,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":734947,"name":"Karen J. Maschke","orcid":"0009-0009-1069-0053","position":1,"is_corresponding":false},{"id":945226,"name":"Jessica Gacki‐Smith","orcid":"0000-0002-7000-9014","position":2,"is_corresponding":false},{"id":1409083,"name":"Hannah L. Brooks","orcid":"0000-0002-5400-3755","position":3,"is_corresponding":false},{"id":1409084,"name":"Margaret M. Matthews","orcid":"0009-0006-1477-0972","position":4,"is_corresponding":false},{"id":1409085,"name":"Karen Traboulsi","orcid":"0009-0000-5224-2974","position":5,"is_corresponding":false},{"id":1240259,"name":"David W. Manning","orcid":"0009-0001-0677-8118","position":6,"is_corresponding":false},{"id":302545,"name":"Joseph R. Leventhal","orcid":"0000-0003-1604-9207","position":7,"is_corresponding":false},{"id":1222075,"name":"Michael K. Gusmano","orcid":"0000-0002-2337-3067","position":8,"is_corresponding":false},{"id":404153,"name":"Elisa J. Gordon","orcid":"0000-0003-0969-1998","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:51:01.235017Z","pmid":"39912498","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}