{"doi":"10.1111/trf.18281","title":"A prospective non‐inferiority trial of pathogen reduced platelets compared to non‐pathogen reduced platelets for correction of viscoelastic platelet function testing in cardiac surgery","abstract":"BACKGROUND: Cardiac surgery on cardiopulmonary bypass (CPB) may alter platelet (PLT) function causing bleeding. The goal of this study is to evaluate the hemostatic effect of PRT-PLTs compared to untreated PLTs stored in platelet additive solution (PAS) following transfusion in bleeding patients undergoing cardiac surgery on CPB. METHODS: In this single-center, prospective single-blinded two-arm noninferiority trial, patients being weaned off CPB were allocated to either a PRT-PLT or a standard PAS-PLT. The primary outcome was the change in maximum amplitude (ΔMA) on thromboelastographic testing (TEG) from pre- to post-transfusion. The non-inferiority margin was chosen as 50% of the ΔMA observed with PAS-PLT using a 1-sided 95% confidence interval. The secondary outcomes included the volume of chest tube drainage (CTD) and the number of blood products transfused during the first 24 h post-surgery. RESULTS: A modified intention-to-treat analysis included 90 patients (48 PRT-PLTs; 42 PAS-PLTs). The ΔMA for PRT-PLT was 2.93 mm (95% CI 1.52-4.34) and was lower than that achieved with PAS-PLT at 5.68 mm (95% CI 3.26-8.09) (2-tailed p = .052). The ratio of ΔMA for PRT-PLT relative to PAS-PLT was estimated at .52 with a 90% confidence interval (.29, .89) and did not meet the non-inferiority criterion (>.5). The CTD and the number of blood products transfused during the first 24 h post-surgery were similar in both arms. CONCLUSION: PRT-PLT transfusion results in lower responses in viscoelastic testing compared to PAS-PLT, although clinical outcomes with respect to blood component utilization and chest tube drainage were similar.","journal":"Transfusion","year":2025,"id":544223,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":472010,"name":"Jackline Joy Lasola","orcid":"0000-0002-1287-6830","position":1,"is_corresponding":false},{"id":1434813,"name":"Aidaelis Martinez‐Hernandez","orcid":null,"position":2,"is_corresponding":false},{"id":1434814,"name":"Juliana N. Marshall","orcid":null,"position":3,"is_corresponding":false},{"id":402645,"name":"Søren M. Bentzen","orcid":"0000-0002-7444-7564","position":4,"is_corresponding":false},{"id":348119,"name":"Min Zhan","orcid":"0000-0002-3776-7884","position":5,"is_corresponding":false},{"id":1434460,"name":"Parvez M. Lokhandwala","orcid":"0000-0003-3571-4102","position":6,"is_corresponding":false},{"id":1019647,"name":"Kenichi A. Tanaka","orcid":"0000-0002-5051-1365","position":7,"is_corresponding":false},{"id":279526,"name":"Carlos H. Villa","orcid":"0000-0002-4632-4751","position":8,"is_corresponding":false},{"id":1434461,"name":"Alexis Jones","orcid":"0000-0003-4955-7929","position":9,"is_corresponding":false},{"id":361178,"name":"Chintamani D. Atreya","orcid":"0000-0001-7393-2157","position":10,"is_corresponding":false},{"id":1228587,"name":"Reney Henderson","orcid":"0000-0003-4701-5827","position":11,"is_corresponding":false},{"id":1245328,"name":"Magali J. Fontaine","orcid":"0000-0001-6731-9516","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T02:53:12.864581Z","pmid":"40371875","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}