{"doi":"10.1111/trf.18195","title":"<scp>HIV</scp> incidence in <scp>US</scp> first‐time blood donors during 12 and 3 month deferral policy periods between 2015 and 2023 before implementation of individual donor assessment","abstract":"BACKGROUND: Following FDA guidance, US blood collectors changed donor deferral for men who have sex with men (MSM) from indefinite to a 12 month deferral in 2016 (12 m), and for MSM and several other exposure risks to 3 month deferrals in 2020 (3 m). We evaluated first-time donor (FTD) HIV incidence and demographics during these periods. STUDY DESIGN AND METHODS: We estimated cross-sectional HIV incidence and incidence rate differences in FTD based on routine donation nucleic acid testing (NAT) and serology with additional limiting antigen (LAg)-Avidity immunoassay and viral load testing. We estimated incidence in the two policy periods (12 and 3 m), incidence trends in two-year intervals between 2015 and 2023, and used multivariable Poisson regression to assess demographic correlates of incident infection. RESULTS: PY (95% CI: 1.18, 2.67), a statistically significant decline (p < .05). Over the period 2015-2023, incidence was stable. Male sex, younger age, Black or African American race, Hispanic ethnicity, and residence in the South were associated with incident infection in regression analysis, but the time-based deferral policy periods were not. DISCUSSION: HIV incidence in FTD did not increase between 2015 and 2023. An overall decline in HIV incidence in the 3 m deferral period compared with the 12 m deferral period was evident. These results provide no indication of an increased residual risk of transfusion-transmitted HIV from FTD in the United States with the reduced deferral periods.","journal":"Transfusion","year":2025,"id":530051,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9333,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258546,"name":"Clara Di Germanio","orcid":"0000-0002-6047-211X","position":1,"is_corresponding":false},{"id":481105,"name":"Edward P. Notari","orcid":"0000-0002-9505-3628","position":2,"is_corresponding":false},{"id":246884,"name":"Mars Stone","orcid":"0000-0001-5619-2767","position":3,"is_corresponding":false},{"id":396420,"name":"Jahnavi Reddy Bhaskar","orcid":null,"position":4,"is_corresponding":false},{"id":1409861,"name":"Venkata Dayana","orcid":null,"position":5,"is_corresponding":false},{"id":257586,"name":"Marion C. Lanteri","orcid":"0000-0002-4213-5013","position":6,"is_corresponding":false},{"id":895280,"name":"Jed B. Gorlin","orcid":"0000-0002-3630-372X","position":7,"is_corresponding":false},{"id":481107,"name":"Rita Reik","orcid":"0000-0001-7345-129X","position":8,"is_corresponding":false},{"id":235417,"name":"Susan L. Stramer","orcid":"0000-0002-5865-6366","position":9,"is_corresponding":false},{"id":36841,"name":"Michael P. Busch","orcid":"0000-0002-1446-125X","position":10,"is_corresponding":false},{"id":1067051,"name":"Benyam Hailu","orcid":null,"position":11,"is_corresponding":false},{"id":28718,"name":"Artur Belov","orcid":"0000-0001-6848-1224","position":12,"is_corresponding":false},{"id":481106,"name":"Hong Yang","orcid":"0000-0002-0057-6566","position":13,"is_corresponding":false},{"id":74337,"name":"Barbee Whitaker","orcid":"0000-0002-6311-6268","position":14,"is_corresponding":false},{"id":24721,"name":"Brian Custer","orcid":"0000-0001-6251-366X","position":15,"is_corresponding":false},{"id":1409862,"name":"the US Transfusion‐Transmissible Infections Monitoring System (TTIMS)","orcid":null,"position":16,"is_corresponding":false},{"id":380882,"name":"Eduard Grebe","orcid":"0000-0001-7046-7245","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-19T02:51:01.235017Z","pmid":"40223180","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}