{"doi":"10.1111/trf.17616","title":"Clinical outcomes in hospitalized plasma and platelet transfusion recipients prior to and following widespread blood donor <scp>SARS‐CoV</scp>‐2 infection and vaccination","abstract":"BACKGROUND: The safety of transfusion of SARS-CoV-2 antibodies in high plasma volume blood components to recipients without COVID-19 is not established. We assessed whether transfusion of plasma or platelet products during periods of increasing prevalence of blood donor SARS-CoV-2 infection and vaccination was associated with changes in outcomes in hospitalized patients without COVID-19. METHODS: We conducted a retrospective cohort study of hospitalized adults who received plasma or platelet transfusions at 21 hospitals during pre-COVID-19 (3/1/2018-2/29/2020), COVID-19 pre-vaccine (3/1/2020-2/28/2021), and COVID-19 post-vaccine (3/1/2021-8/31/2022) study periods. We used multivariable logistic regression with generalized estimating equations to adjust for demographics and comorbidities to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Among 21,750 hospitalizations of 18,584 transfusion recipients without COVID-19, there were 697 post-transfusion thrombotic events, and oxygen requirements were increased in 1751 hospitalizations. Intensive care unit length of stay (n = 11,683) was 3 days (interquartile range 1-5), hospital mortality occurred in 3223 (14.8%), and 30-day rehospitalization in 4144 (23.7%). Comparing the pre-COVID, pre-vaccine and post-vaccine study periods, there were no trends in thromboses (OR 0.9 [95% CI 0.8, 1.1]; p = .22) or oxygen requirements (OR 1.0 [95% CI 0.9, 1.1]; p = .41). In parallel, there were no trends across study periods for ICU length of stay (p = .83), adjusted hospital mortality (OR 1.0 [95% CI 0.9-1.0]; p = .36), or 30-day rehospitalization (p = .29). DISCUSSION: Transfusion of plasma and platelet blood components collected during the pre-vaccine and post-vaccine periods of the COVID-19 pandemic was not associated with increased adverse outcomes in transfusion recipients without COVID-19.","journal":"Transfusion","year":2023,"id":364946,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235809,"name":"J Greene","orcid":"0000-0002-0859-6828","position":1,"is_corresponding":false},{"id":373990,"name":"Vincent X. Liu","orcid":"0000-0001-6899-9998","position":2,"is_corresponding":false},{"id":313721,"name":"Catherine Lee","orcid":"0000-0003-0008-9052","position":3,"is_corresponding":false},{"id":662862,"name":"Dustin G. Mark","orcid":"0000-0002-5001-7228","position":4,"is_corresponding":false},{"id":426743,"name":"David R. Vinson","orcid":"0000-0001-6559-1858","position":5,"is_corresponding":false},{"id":381667,"name":"Bryan R. Spencer","orcid":"0000-0002-9008-9154","position":6,"is_corresponding":false},{"id":324056,"name":"Roberta Bruhn","orcid":"0000-0002-5898-8168","position":7,"is_corresponding":false},{"id":321168,"name":"Marjorie D. Bravo","orcid":"0000-0003-3562-5556","position":8,"is_corresponding":false},{"id":246884,"name":"Mars Stone","orcid":"0000-0001-5619-2767","position":9,"is_corresponding":false},{"id":24721,"name":"Brian Custer","orcid":"0000-0001-6251-366X","position":10,"is_corresponding":false},{"id":300022,"name":"Steve Kleinman","orcid":null,"position":11,"is_corresponding":false},{"id":36841,"name":"Michael P. Busch","orcid":"0000-0002-1446-125X","position":12,"is_corresponding":false},{"id":284370,"name":"Philip J. Norris","orcid":"0000-0003-0526-2088","position":13,"is_corresponding":false},{"id":1120499,"name":"for the NHLBI Recipient Epidemiology and Donor Evaluation Study‐IV‐P (REDS‐IV)","orcid":null,"position":14,"is_corresponding":false},{"id":321172,"name":"Nareg H. Roubinian","orcid":"0000-0002-1063-6155","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T01:14:41.218128Z","pmid":"38054619","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}