{"doi":"10.1111/trf.17318","title":"Multi‐institutional experience with COVID‐19 convalescent plasma in children","abstract":"BACKGROUND AND OBJECTIVES: Convalescent COVID-19 plasma (CCP) was developed and used worldwide as a treatment option by supplying passive immunity. Adult studies suggest administering high-titer CCP early in the disease course of patients who are expected to be antibody-negative; however, pediatric experience is limited. We created a multi-institutional registry to characterize pediatric patients (<18 years) who received CCP and to assess the safety of this intervention. METHODS: A REDCap survey was distributed. The registry collected de-identified data including demographic information (age, gender, and underlying conditions), COVID-19 disease features and concurrent treatments, CCP transfusion and safety events, and therapy response. RESULTS: Ninety-five children received CCP: 90 inpatients and 5 outpatients, with a median age of 10.2 years (range 0-17.9). They were predominantly Latino/Hispanic and White. The most frequent underlying medical conditions were chronic respiratory disease, immunosuppression, obesity, and genetic syndromes. CCP was primarily given as a treatment (95%) rather than prophylaxis (5%). Median total plasma dose administered and transfusion rates were 5.0 ml/kg and 2.6 ml/kg/h, respectively. The transfusions were well-tolerated, with 3 in 115 transfusions reporting mild reactions. No serious adverse events were reported. Severity scores decreased significantly 7 days after CCP transfusion or at discharge. Eighty-five patients (94.4%) survived to hospital discharge. All five outpatients survived to 60 days. CONCLUSIONS: CCP was found to be safe and well-tolerated in children. CCP was frequently given concurrently with other COVID-19-directed treatments with improvement in clinical severity scores ≥7 days after CCP, but efficacy could not be evaluated in this study.","journal":"Transfusion","year":2023,"id":374479,"datarank":0.27016381417287816,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.028748127307763084,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.028748127307763084,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04377672"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":506158,"name":"Oren Gordon","orcid":"0000-0002-3159-8426","position":1,"is_corresponding":false},{"id":1136472,"name":"Daniel K. Noland","orcid":null,"position":2,"is_corresponding":false},{"id":59344,"name":"Jeffrey R. Donowitz","orcid":"0000-0003-4816-4728","position":3,"is_corresponding":false},{"id":664688,"name":"Emily R. Levy","orcid":"0000-0001-8447-7663","position":4,"is_corresponding":false},{"id":241543,"name":"Sanjay K. Jain","orcid":"0000-0001-9620-7070","position":5,"is_corresponding":false},{"id":449235,"name":"Zachary Willis","orcid":"0000-0002-6372-5274","position":6,"is_corresponding":false},{"id":274832,"name":"Casey A. Rimland","orcid":"0000-0002-5187-6921","position":7,"is_corresponding":false},{"id":758890,"name":"Michele Loi","orcid":"0000-0002-6090-6336","position":8,"is_corresponding":false},{"id":342565,"name":"Antonio Arrieta","orcid":"0000-0001-9281-8915","position":9,"is_corresponding":false},{"id":758891,"name":"Kyle Annen","orcid":"0000-0002-7192-5057","position":10,"is_corresponding":false},{"id":1136473,"name":"Noelle Drapeau","orcid":null,"position":11,"is_corresponding":false},{"id":1136040,"name":"Stephanie Osborne","orcid":"0000-0001-7050-6275","position":12,"is_corresponding":false},{"id":91687,"name":"Monica I. 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