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In the absence of <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content>, integrins are increasingly retained inside the cell, traffic toward the perinuclear lysosomal compartment and their degradation is enhanced. Integrin traffic and maintenance of integrin levels are dependent on the integrity of the Arf binding site of <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content>. Furthermore, sorting nexin 17 (<jats:styled-content style=\"fixed-case\">SNX17</jats:styled-content>), a critical regulator of integrin recycling, becomes mislocalized to enlarged late endosomes upon <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content> depletion. These data support a model whereby <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content>, through its ability to regulate <jats:styled-content style=\"fixed-case\">SNX17</jats:styled-content> endosomal localization and through interaction with Arf6 diverts integrins from the degradative pathway supporting cell migration.</jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"graphic/tra12390-gra-0001.png\" xlink:title=\"image\"/></jats:p>","journal":"Traffic","year":2016,"id":666927,"datarank":0.5806801516361837,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"self_citation_contribution":0.5806801516361837,"citation_network_contribution":0.0,"self_endowment_contribution":0.5806801516361837,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":648036,"name":"Pranshu Sahgal","orcid":"0000-0002-9857-3987","position":1,"is_corresponding":false},{"id":1741621,"name":"Christine A. 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Here we identify a role for Golgi‐localized gamma‐ear containing Arf‐binding protein 3 (<jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content>), in regulating trafficking of β1 integrin. <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content> knockdown reduces cell surface and total levels of α2, α5 and β1 integrin subunits, inhibits cell spreading, reduces focal adhesion number, as well as cell migration. In the absence of <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content>, integrins are increasingly retained inside the cell, traffic toward the perinuclear lysosomal compartment and their degradation is enhanced. Integrin traffic and maintenance of integrin levels are dependent on the integrity of the Arf binding site of <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content>. Furthermore, sorting nexin 17 (<jats:styled-content style=\"fixed-case\">SNX17</jats:styled-content>), a critical regulator of integrin recycling, becomes mislocalized to enlarged late endosomes upon <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content> depletion. These data support a model whereby <jats:styled-content style=\"fixed-case\">GGA3</jats:styled-content>, through its ability to regulate <jats:styled-content style=\"fixed-case\">SNX17</jats:styled-content> endosomal localization and through interaction with Arf6 diverts integrins from the degradative pathway supporting cell migration.</jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"graphic/tra12390-gra-0001.png\" xlink:title=\"image\"/></jats:p>","is_dataset_classified":null,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26935970","pmcid":null,"openalex_id":"https://openalex.org/W2291092743","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"MOP‐11545","title":null},{"funder_name":"European Research Council","grant_id":"615258","title":"Adhesion switches in cancer and development: from in vivo to synthetic biology"},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Suomen Akatemia","grant_id":"","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"","title":null},{"funder_name":"CIHR","grant_id":"","title":null},{"funder_name":"CIHR","grant_id":"","title":null}],"total_grants":7,"fwci":3.5168,"citation_percentile":0.92084423,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":9},{"year":2019,"count":9},{"year":2020,"count":5},{"year":2021,"count":2},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":5}],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tra.12390","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tra.12390","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftra.12390","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/tra.12390","host_type":"publisher"},{"url":"https://doi.org/10.1111/tra.12390","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26935970","host_type":"repository"},{"url":"http://juuli.fi/Record/0252268616","host_type":""},{"url":"https://dx.doi.org/10.1111/tra.12390","host_type":""},{"url":"http://dx.doi.org/10.1111/tra.12390","host_type":""}],"fields_of_study":["Cellular transport and secretion","Cell Adhesion Molecules Research","Cellular Mechanics and Interactions","0301 basic medicine","0303 health sciences","03 medical and health sciences","ADP-Ribosylation Factors","Adaptor Proteins, Vesicular Transport","Cell Adhesion","Cell Movement","Endosomes","Golgi Apparatus","HeLa Cells","Humans","Integrin beta1","Protein Binding","Protein Transport","Sorting Nexins"],"mesh_terms":["Cell Adhesion","Cell Movement","Golgi Apparatus","HeLa Cells","Humans","Protein Binding","Endosomes","Integrin beta1","ADP-Ribosylation Factors","Protein Transport","Adaptor Proteins, Vesicular Transport","Sorting Nexins","Hela Cells"],"keywords":["Endosome","Cell biology","Integrin","CD49c","Integrin, beta 6","Cell adhesion","Cell migration","Collagen receptor","Sorting nexin","Biology","Actin cytoskeleton","Signal transducing adaptor protein","Intracellular","Cytoskeleton","Cell","Signal transduction","Biochemistry","Recycling","Gga3","ADP-Ribosylation Factors","Integrin beta1","ta1182","Golgi Apparatus","Endosomes","Adaptor Proteins, Vesicular Transport","Protein Transport","Cell Movement","Humans","Sorting Nexins","HeLa Cells","Protein Binding"],"sdg_mappings":[{"sdg_number":12,"sdg_label":"12. 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