{"doi":"10.1111/tpj.12818","title":"<scp>PRC</scp>1 is taking the lead in <scp>P</scp>c<scp>G</scp> repression","abstract":"<jats:title>Summary</jats:title><jats:p>Polycomb group (PcG) proteins constitute a major epigenetic mechanism for gene repression throughout the plant life. For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes (<jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>s) to target genes in which the binding of <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>2 and the incorporation of H3 lysine 27 trimethyl marks led to recruitment of <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>1, which in turn mediated H2A monoubiquitination. However, recent studies have turned this model upside‐down by showing that <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>1 activity can be required for <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>2 recruitment and H3K27me3 marking. Here, we review the current knowledge on plant <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>1 composition and mechanisms of repression, as well as its role during plant development.</jats:p>","journal":"The Plant Journal","year":2015,"id":617141,"datarank":2.2819096373087735,"base_score":4.442651256490317,"endowment":4.442651256490317,"self_citation_contribution":0.6663976884735476,"citation_network_contribution":1.615511948835226,"self_endowment_contribution":0.6663976884735476,"citer_contribution":1.615511948835226,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":61,"citers_with_citation_signal":51,"citers_with_endowment":51,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1591352,"name":"Myriam Calonje","orcid":null,"position":1,"is_corresponding":false},{"id":1591350,"name":"Wiam Merini","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<scp>PRC</scp>1 is taking the lead in <scp>P</scp>c<scp>G</scp> repression","abstract":"<jats:title>Summary</jats:title><jats:p>Polycomb group (PcG) proteins constitute a major epigenetic mechanism for gene repression throughout the plant life. For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes (<jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>s) to target genes in which the binding of <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>2 and the incorporation of H3 lysine 27 trimethyl marks led to recruitment of <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>1, which in turn mediated H2A monoubiquitination. However, recent studies have turned this model upside‐down by showing that <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>1 activity can be required for <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>2 recruitment and H3K27me3 marking. Here, we review the current knowledge on plant <jats:styled-content style=\"fixed-case\">PRC</jats:styled-content>1 composition and mechanisms of repression, as well as its role during plant development.</jats:p>","is_dataset_classified":null,"base_score":4.442651256490317,"endowment":4.442651256490317,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25754661","pmcid":null,"openalex_id":"https://openalex.org/W2118905618","authors":[],"funders":[{"funder_name":"Ministerio de Economía y Competitividad","grant_id":"BIO2013-44078-P","title":null},{"funder_name":"Marie Curie CIG","grant_id":"ID 333748","title":null},{"funder_name":"European Commission","grant_id":"333748","title":"Do plants go further in deciding their cell fate: different target genes, different Polycomb Group mechanisms?"}],"total_grants":3,"fwci":14.8884,"citation_percentile":0.9889748,"influential_citations":0,"citation_trend":[{"year":2015,"count":5},{"year":2016,"count":7},{"year":2017,"count":13},{"year":2018,"count":6},{"year":2019,"count":4},{"year":2020,"count":3},{"year":2021,"count":10},{"year":2022,"count":8},{"year":2023,"count":18},{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tpj.12818","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tpj.12818","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftpj.12818","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/tpj.12818","host_type":"publisher"},{"url":"https://doi.org/10.1111/tpj.12818","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25754661","host_type":"repository"},{"url":"https://idus.us.es/handle//11441/84509","host_type":"repository"},{"url":"http://hdl.handle.net/10261/123078","host_type":"repository"},{"url":"https://idus.us.es/bitstream/11441/84509/1/PRC1.pdf","host_type":""},{"url":"https://hdl.handle.net/11441/84509","host_type":""},{"url":"https://dx.doi.org/10.1111/tpj.12818","host_type":""}],"fields_of_study":["Plant Molecular Biology Research","Epigenetics and DNA Methylation","Plant Genetic and Mutation Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences","Arabidopsis Proteins","Gene Expression Regulation, Plant","Glucosyltransferases","Plant Development","Plant Proteins","Polycomb-Group Proteins"],"mesh_terms":["Glucosyltransferases","Plant Proteins","Gene Expression Regulation, Plant","Arabidopsis Proteins","Polycomb-Group Proteins","Plant Development"],"keywords":["Psychological repression","PRC2","Epigenetics","Mechanism (biology)","Cell biology","Gene","Biology","Genetics","Histone H3","Gene expression","Physics","Arabidopsis","Plant development","Gene repression","Prc1","Polycomb Group","H2a Monoubiquitination","Chromatin Compaction","Arabidopsis Proteins","Polycomb-Group Proteins","Gene Expression Regulation, Plant","Glucosyltransferases","Plant Proteins"],"sdg_mappings":[{"sdg_number":7,"sdg_label":"7. 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