{"doi":"10.1111/tmi.13364","title":"Use of pre‐ART laboratory screening to identify renal, hepatic and haematological abnormalities in Côte d'Ivoire","abstract":"BACKGROUND: High demand for HIV-services and extensive clinical guidelines force health systems in low-resource settings to dedicate resources to service delivery at the expense of other priorities. Simplifying services may reduce the burden on health systems and pre-antiretroviral therapy (ART) laboratory screening is among the services under consideration for simplification. METHODS: We assessed the frequencies of conditions linked to ART toxicities among 34,994 adult, ART-naïve patients with specimens referred to the RETRO-CI laboratory in Abidjan, Côte d'Ivoire between 1998 and 2017. Screening included tests for serum creatinine, alanine aminotransferase (ALT) and haemoglobin (Hb) to identify renal dysfunction (estimated glomerular filtration rate < 50 mL/min), hepatic abnormalities (ALT > 5× upper limit of normal) and severe anaemia (Hb < 6.5 g/dL), respectively. We considered screening results across four eras and identified factors associated with the conditions in question. RESULTS: The prevalence of renal dysfunction, hepatic abnormalities and severe anaemia were largely unchanged over time and just 8.4% of patients had any of the three conditions. Key factors associated with renal dysfunction and severe anaemia were age > 50 years (adjusted odds ratio (aOR): 2.53; 95% confidence interval (CI): 2.19-2.92; P < 0.001) and CD4 < 100 cells/µl (aOR: 2.57; 95% CI: 2.30-2.88; P < 0.001). CONCLUSION: The relative infrequency of conditions linked to toxicity in Côte d'Ivoire supports the notion that simplification of pre-ART laboratory screening may be undertaken with limited negative impact on identification of adverse events. Targeted screening may be a feasible strategy to balance detection of conditions associated with ART toxicities with simplification of services.","journal":"Tropical Medicine & International Health","year":2020,"id":128765,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":579481,"name":"Christiane Adjé-Touré","orcid":"0000-0002-0745-6313","position":1,"is_corresponding":false},{"id":145769,"name":"G. Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":580056,"name":"André Tehe","orcid":null,"position":3,"is_corresponding":false},{"id":431236,"name":"Judith Hedje","orcid":null,"position":4,"is_corresponding":false},{"id":580057,"name":"Erin Rottinghaus","orcid":null,"position":5,"is_corresponding":false},{"id":580058,"name":"K. Natacha","orcid":null,"position":6,"is_corresponding":false},{"id":548519,"name":"Karidia Diallo","orcid":"0000-0001-7767-9638","position":7,"is_corresponding":false},{"id":580059,"name":"G. Laïssa Ouedraogo","orcid":null,"position":8,"is_corresponding":false},{"id":388629,"name":"John N. Nkengasong","orcid":"0000-0001-6047-0184","position":9,"is_corresponding":false},{"id":579480,"name":"Peter A. Minchella","orcid":"0000-0002-6295-0998","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:15:42.522809Z","pmid":"31960558","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}