{"doi":"10.1111/tme.12766","title":"<scp>HIV</scp> primary drug resistance and associated <scp>HIV</scp> risk factors among <scp>HIV</scp> positive blood donors in Brazil from 2007 to 2017","abstract":"BACKGROUND: Acquisition of HIV primary drug resistant (PDR) infection can lead to poor virologic and clinical outcomes in individuals and hampers public health efforts in epidemic control. Monitoring PDR in HIV-positive blood donors can be used to inform nationwide trends in the spread of drug-resistant HIV strains. METHODS: We conducted a cross-sectional study using genetic sequence analysis to assess HIV pol sequences, PDR, and risk factors for infection using audio computer-assisted structured interviews in four large blood centers in Brazil from 2007 to 2017. RESULTS: Of 716 HIV-positive blood donors, 504 (70.4%) were successfully sequenced. HIV clade B (73.2%) was the most prevalent subtype, followed by a mix of non-B (21.2%) sub-types. A twofold increase (from 4% to 8%) in recombinants prevalence was observed during the study period. Sixty-four (12.7%) presented PDR. Overall, HIV PDR prevalence remained stable during the study period. Drug resistance mutations for non-nucleoside reverse transcriptase inhibitors were found in 39 (7.7%) donors, while for nucleoside reverse transcriptase inhibitors were found in 26 (5.1%), and for protease inhibitors in 24 (4.8%) of HIV-infected donors. We did not find statistically significant differences in demographics, behavioural risk factors, or HIV genotypes when comparing volunteers with and without PDR. CONCLUSION: The HIV PDR rate among donors remained stable during the study period. HIV-positive blood donors can be an informative population to monitor primary HIV resistance and ultimately may help to increase the knowledge and awareness of HIV risk factors and PDR.","journal":"Transfusion Medicine","year":2021,"id":211691,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8812,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":387951,"name":"Tassila Salomon","orcid":"0000-0002-8123-3118","position":1,"is_corresponding":false},{"id":387947,"name":"Cecília Salete Alencar","orcid":"0000-0002-3583-2275","position":2,"is_corresponding":false},{"id":387945,"name":"Thelma T. Gonçalez","orcid":"0000-0001-5753-7026","position":3,"is_corresponding":false},{"id":149534,"name":"Ester Sabino","orcid":"0000-0003-2623-5126","position":4,"is_corresponding":false},{"id":387958,"name":"Liliana Preiss","orcid":"0000-0002-2978-7260","position":5,"is_corresponding":false},{"id":387939,"name":"Paula Loureiro","orcid":"0000-0003-1849-0047","position":6,"is_corresponding":false},{"id":723258,"name":"Maria Esther Lopes","orcid":"0000-0003-1477-6654","position":7,"is_corresponding":false},{"id":387950,"name":"Carolina Miranda Teixeira","orcid":"0000-0002-0774-4032","position":8,"is_corresponding":false},{"id":801723,"name":"Mariana Mundim","orcid":null,"position":9,"is_corresponding":false},{"id":387938,"name":"Anna Bárbara de Freitas Carneiro-Proietti","orcid":"0000-0003-4302-5817","position":10,"is_corresponding":false},{"id":360579,"name":"Cesar de Almeida‐Neto","orcid":"0000-0002-8490-4634","position":11,"is_corresponding":false},{"id":24721,"name":"Brian Custer","orcid":"0000-0001-6251-366X","position":12,"is_corresponding":false},{"id":339107,"name":"Carlos Henrique Valente Moreira","orcid":"0000-0002-4187-5482","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-18T23:52:20.112538Z","pmid":"33665900","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}