{"doi":"10.1111/tid.70135","title":"Hospital‐Acquired Respiratory Viral Infections (HA‐RVIs) Over 10 Years Disproportionally Affect the Immunocompromised","abstract":"INTRODUCTION: Respiratory viral infections (RVIs) such as influenza (Flu), respiratory syncytial virus (RSV), and parainfluenza (PIV) are associated with increased morbidity and mortality among immunocompromised patients. METHODS: A community-acquired (CA)-Flu/RSV/PIV case was defined as a positive laboratory result collected < 72 h after inpatient admission, whereas an HA-Flu/RSV/PIV case was defined as a positive result collected ≥ 72 h after inpatient admission. RESULTS: During the study period, 6.6% of Flu cases, 12.2% of RSV cases, and 10.9% of PIV cases were HA. Patients with a cancer diagnosis were more prevalent in the HA-Flu (24.3% vs. 11.8%) and HA-RSV (26.7% vs. 11.9%) groups compared to their CA counterparts. Patients who received chemotherapy within the past 30 days were more prevalent in the HA-Flu (10.8% vs. 4.4%), HA-RSV (20.0% vs. 8.1%), and HA-PIV (4.2% vs. 0.7%) groups compared to their CA counterparts. Recipients of SCT within the last year were more prevalent in the HA-Flu (6.3% vs. 2.3%) and HA-RSV (10.7% vs. 3.7%) groups compared to their CA counterparts. In the overall cohort, HA-Flu, HA-RSV, and HA-PIV were all associated with a higher likelihood of ICU admission. HA-Flu was additionally associated with a higher risk of mechanical ventilation, renal replacement therapy, and death compared to CA-Flu. DISCUSSION: Immunocompromised patients are heavily represented among HA cases, pointing to a need for targeted infection prevention and control interventions for vulnerable patient populations during periods of high RVI community transmission.","journal":"Transplant Infectious Disease","year":2025,"id":583340,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8441,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":283127,"name":"Hannah Nam","orcid":"0000-0003-4576-287X","position":1,"is_corresponding":false},{"id":283132,"name":"Michael G. Ison","orcid":"0000-0003-3347-9671","position":2,"is_corresponding":false},{"id":1495527,"name":"Shardul N Rathod","orcid":"0000-0002-9768-4095","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T02:59:03.725721Z","pmid":"41288352","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}