{"doi":"10.1111/tid.14213","title":"Twelve‐month kidney and liver outcomes of kidney transplantation from Hepatitis C Viremic deceased donors to aviremic recipients","abstract":"INTRODUCTION: Utilization of hepatitis C viremic (HCV+) deceased donor kidneys (DDKT) for aviremic recipients increases opportunities for transplantation with excellent short-term outcomes. Our primary aim was to understand longer-term outcomes, specifically assessing kidney and liver function in the first year posttransplant. METHODS: This was a retrospective single-center study of adult DDKT recipients of HCV+ kidneys (cases) matched 1:1 to recipients of HCV- kidneys (comparators). Between-group outcomes were analyzed using comparisons of means and proportions, survival analysis methods, and multivariable mixed effects models. RESULTS: Sixty-five cases and 65 comparators had statistically comparable demographic and clinical characteristics. There were no between-group differences in serum creatinine or estimated glomerular filtration rate at month 12 (p = .662) or in their trajectories over months 1-12 (p > .292). Within the first 60 days, rates of liver function values >3 times upper limit of normal among cases were comparable to comparators for aspartate aminotransferase (AST) (14% vs. 6%, p = .242) and higher for alanine transaminase (ALT) (23% vs. 6%, p = .011). AST declined during the first 8 weeks (p = .005) and stabilized for both groups (p = .406) during the following 10 months. ALT declined during the first 8 weeks (p < .001), continued to decline over months 3-12 (p = .016), and the trajectory was unrelated to antiviral therapy initiation among cases. CONCLUSIONS: Aviremic recipients of HCV+ kidneys had comparable kidney outcomes to matched recipients of HCV- kidneys. Despite more HCV+ recipients having an elevation in ALT within the first 60 days, ALT values normalized with no identified liver complications attributed to HCV.","journal":"Transplant Infectious Disease","year":2023,"id":387236,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9449,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1156029,"name":"Peter E. Thorne","orcid":"0009-0000-3021-4024","position":1,"is_corresponding":false},{"id":781245,"name":"Scott A. Rega","orcid":"0000-0003-2205-2314","position":2,"is_corresponding":false},{"id":781244,"name":"Irene D. Feurer","orcid":"0000-0001-5444-5695","position":3,"is_corresponding":false},{"id":1156030,"name":"Saed Shawar","orcid":"0000-0002-4602-5700","position":4,"is_corresponding":false},{"id":1156414,"name":"Ruchi Naik","orcid":null,"position":5,"is_corresponding":false},{"id":384869,"name":"Kelly A. Birdwell","orcid":"0000-0002-7996-3947","position":6,"is_corresponding":false},{"id":1156415,"name":"J. Harold Helderman","orcid":null,"position":7,"is_corresponding":false},{"id":1156031,"name":"Anthony Langone","orcid":"0000-0003-4758-6582","position":8,"is_corresponding":false},{"id":1156032,"name":"Bonnie Ann Sarrell","orcid":"0000-0001-6045-9030","position":9,"is_corresponding":false},{"id":1156033,"name":"Heidi Schaefer","orcid":"0000-0001-5058-2684","position":10,"is_corresponding":false},{"id":1156034,"name":"Bernard J. DuBray","orcid":"0000-0001-8021-5658","position":11,"is_corresponding":false},{"id":1156416,"name":"Kareem Eid","orcid":null,"position":12,"is_corresponding":false},{"id":1156035,"name":"Laura Hickman","orcid":"0000-0003-4585-3413","position":13,"is_corresponding":false},{"id":625149,"name":"David R. Shaffer","orcid":"0000-0002-3040-7499","position":14,"is_corresponding":false},{"id":486538,"name":"Beatrice P. Concepcion","orcid":"0000-0002-0576-6756","position":15,"is_corresponding":false},{"id":486539,"name":"Rachel C. Forbes","orcid":"0000-0001-6827-791X","position":16,"is_corresponding":false},{"id":727522,"name":"Laura Binari","orcid":"0009-0002-4899-3382","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T01:18:04.706547Z","pmid":"38112078","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}