{"doi":"10.1111/tid.13783","title":"Impact of donor multidrug‐resistant organisms on solid organ transplant recipient outcomes","abstract":"BACKGROUND: The impact of donor colonization or infection with multidrug-resistant organisms (MDROs) on solid organ transplant (SOT) recipient outcomes remains uncertain. We thus evaluated the association between donor MDROs and risk of posttransplant infection, graft failure, and mortality. METHODS: A multicenter retrospective cohort study was performed. All SOT recipients with a local deceased donor were included. The cohort was divided into three exposure groups: recipients whose donors had (1) an MDRO, (2) a non-MDRO bacterial or candidal organism, or (3) no growth on cultures. The primary outcomes were (1) bacterial or invasive candidal infection within 3 months and (2) graft failure or death within 12 months posttransplant. Mixed effect multivariable frailty models were developed to evaluate each association. RESULTS: Of 658 total SOT recipients, 93 (14%) had a donor with an MDRO, 477 (73%) had a donor with a non-MDRO organism, and 88 (13%) had a donor with no organisms on culture. On multivariable analyses, donor MDROs were associated with a significantly increased hazard of infection compared to those with negative donor cultures (adjust hazard ratio [aHR] 1.63, 95% CI 1.01-2.62, p = .04) but were not associated with graft failure or death (aHR 0.45, 95% CI 0.15-1.36, p = .16). CONCLUSIONS: MDROs on donor culture increase the risk of early posttransplant infection but do not appear to affect long-term graft or recipient survival, suggesting organ donors with MDROs on culture may be safely utilized. Future studies aimed at reducing early posttransplant infections associated with donor MDROs are needed.","journal":"Transplant Infectious Disease","year":2021,"id":170467,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9321,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":460815,"name":"Emily A. Blumberg","orcid":"0000-0002-5193-6170","position":1,"is_corresponding":false},{"id":287737,"name":"Jennifer Han","orcid":"0000-0003-4744-8067","position":2,"is_corresponding":false},{"id":526743,"name":"Dong Heun Lee","orcid":"0000-0002-1860-3446","position":3,"is_corresponding":false},{"id":703288,"name":"Heather Clauss","orcid":"0000-0003-3104-1844","position":4,"is_corresponding":false},{"id":29344,"name":"Richard Hasz","orcid":"0000-0002-8830-162X","position":5,"is_corresponding":false},{"id":704117,"name":"Esther Molnar","orcid":null,"position":6,"is_corresponding":false},{"id":703289,"name":"Darcy Alimenti","orcid":"0000-0002-6658-7882","position":7,"is_corresponding":false},{"id":703290,"name":"Andrew R. Motzer","orcid":"0000-0001-9795-5273","position":8,"is_corresponding":false},{"id":703291,"name":"Sharon West","orcid":"0000-0003-2436-2869","position":9,"is_corresponding":false},{"id":356701,"name":"Warren B. Bilker","orcid":"0000-0002-2704-7525","position":10,"is_corresponding":false},{"id":460816,"name":"Pam Tolomeo","orcid":"0000-0001-5594-8884","position":11,"is_corresponding":false},{"id":287738,"name":"Ebbing Lautenbach","orcid":"0000-0003-4772-2409","position":12,"is_corresponding":false},{"id":460814,"name":"Judith A. Anesi","orcid":"0000-0001-6671-4557","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-18T23:46:24.040760Z","pmid":"34968006","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}