{"doi":"10.1111/resp.12862","title":"Heterogeneity of incidence and outcome of acute exacerbation in idiopathic interstitial pneumonia","abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT</jats:styled-content>\n</jats:title><jats:sec><jats:title>Background and objective</jats:title><jats:p>Acute exacerbations (<jats:styled-content style=\"fixed-case\">AEs</jats:styled-content>) of idiopathic pulmonary fibrosis (<jats:styled-content style=\"fixed-case\">IPF</jats:styled-content>) and other idiopathic interstitial pneumonia (<jats:styled-content style=\"fixed-case\">IIP</jats:styled-content>) have a poor prognosis. This study aims to clarify the incidence and prognosis of <jats:styled-content style=\"fixed-case\">AE</jats:styled-content> in <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content> and the other <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of 229 patients were enrolled, of whom 92 had <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content> and 137 had ‘<jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> other than <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content>’ based on the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association (<jats:styled-content style=\"fixed-case\">ATS</jats:styled-content>/<jats:styled-content style=\"fixed-case\">ERS</jats:styled-content>/<jats:styled-content style=\"fixed-case\">JRS</jats:styled-content>/<jats:styled-content style=\"fixed-case\">ALAT</jats:styled-content>) 2011 IPF Guidelines. <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> other than <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content> included 11 patients with a surgical lung biopsy (<jats:styled-content style=\"fixed-case\">SLB</jats:styled-content>) and the remainder without such a biopsy. <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> other than <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content> was further classified into <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> with a ‘possible usual interstitial pneumonia (<jats:styled-content style=\"fixed-case\">UIP</jats:styled-content>)’ pattern on <jats:styled-content style=\"fixed-case\">HRCT</jats:styled-content> (<jats:italic>n</jats:italic> = 75) and <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> with ‘inconsistent with <jats:styled-content style=\"fixed-case\">UIP</jats:styled-content>’ pattern (<jats:italic>n</jats:italic> = 62) based on published guidelines. Predictors of <jats:styled-content style=\"fixed-case\">AE</jats:styled-content> and the prognosis after <jats:styled-content style=\"fixed-case\">AE</jats:styled-content> were examined in these groups.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The 1‐year incidence of <jats:styled-content style=\"fixed-case\">AE</jats:styled-content> in <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content>, <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> with possible <jats:styled-content style=\"fixed-case\">UIP HRCT</jats:styled-content> patterns and <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> with inconsistent with <jats:styled-content style=\"fixed-case\">UIP HRCT</jats:styled-content> patterns was 16.5%, 8.9% and 4.0%, respectively. <jats:styled-content style=\"fixed-case\">AE</jats:styled-content> occurred significantly more frequently in <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content> than in <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> with possible <jats:styled-content style=\"fixed-case\">UIP</jats:styled-content> and inconsistent with <jats:styled-content style=\"fixed-case\">UIP HRCT</jats:styled-content> patterns after adjustment for <jats:styled-content style=\"fixed-case\">BMI</jats:styled-content>, modified Medical Research Council score and %forced vital capacity. Prognosis of <jats:styled-content style=\"fixed-case\">AE‐IIP</jats:styled-content> with possible <jats:styled-content style=\"fixed-case\">UIP HRCT</jats:styled-content> pattern was significantly worse than that of <jats:styled-content style=\"fixed-case\">AE‐IPF</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Although <jats:styled-content style=\"fixed-case\">AE</jats:styled-content> occurred significantly less frequently in <jats:styled-content style=\"fixed-case\">IIP</jats:styled-content> with possible <jats:styled-content style=\"fixed-case\">UIP</jats:styled-content> and inconsistent <jats:styled-content style=\"fixed-case\">with UIP HRCT</jats:styled-content> patterns than in <jats:styled-content style=\"fixed-case\">IPF</jats:styled-content>, the prognosis of <jats:styled-content style=\"fixed-case\">AE‐IIP</jats:styled-content> with possible <jats:styled-content style=\"fixed-case\">UIP HRCT</jats:styled-content> patterns might be worse than that of <jats:styled-content style=\"fixed-case\">AE‐IPF</jats:styled-content>.</jats:p></jats:sec>","journal":"Respirology","year":2016,"id":22455,"datarank":2.0175737397493068,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":1.433800695032713,"self_endowment_contribution":0.5837730447165941,"citer_contribution":1.433800695032713,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":38,"citers_with_citation_signal":31,"citers_with_endowment":31,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":141117,"name":"Tomoko Kagawa","orcid":null,"position":1,"is_corresponding":false},{"id":141118,"name":"Yumiko 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