{"doi":"10.1111/ppe.13097","title":"Low‐dose aspirin, maternal cardiometabolic health, and offspring respiratory health 9 to 14 years after delivery: Findings from the <scp>EAGeR</scp> Follow‐up Study","abstract":"BACKGROUND: Accumulating evidence shows that peri-conceptional and in-utero exposures have lifetime health impacts for mothers and their offspring. OBJECTIVES: We conducted a Follow-Up Study of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial with two objectives. First, we determined if women who enrolled at the Utah site (N = 1001) of the EAGeR trial (2007-2011, N = 1228) could successfully be contacted and agree to complete an online questionnaire on their reproductive, cardio-metabolic, and offspring respiratory health 9-14 years after original enrollment. Second, we evaluated if maternal exposure to low-dose aspirin (LDA) during pregnancy was associated with maternal cardio-metabolic health and offspring respiratory health. METHODS: The original EAGeR study population included women, 18-40 years of age, who had 1-2 prior pregnancy losses, and who were trying to become pregnant. At follow-up (2020-2021), participants from the Utah cohort completed a 13-item online questionnaire on reproductive and cardio-metabolic health, and those who had a live birth during EAGeR additionally completed a 7-item questionnaire on the index child's respiratory health. Primary maternal outcomes included hypertension and hypercholesterolemia; primary offspring outcomes included wheezing and asthma. RESULTS: Sixty-eight percent (n = 678) of participants enrolled in the follow-up study, with 10% and 15% reporting maternal hypertension and hypercholesterolemia, respectively; and 18% and 10% reporting offspring wheezing and asthma. We found no association between maternal LDA exposure and hypertension (risk difference [RD] -0.001, 95% confidence interval [CI] -0.05, 0.04) or hypercholesterolemia (RD -0.01, 95% CI -0.06, 0.05) at 9-14 years follow-up. Maternal LDA exposure was not associated with offspring wheezing (RD -0.002, 95% CI -0.08, 0.08) or asthma (RD 0.13, 95% CI 0.11, 0.37) at follow-up. Findings remained robust after considering potential confounding and selection bias. CONCLUSIONS: We observed no association between LDA exposure during pregnancy and maternal cardiometabolic or offspring respiratory health.","journal":"Paediatric and Perinatal Epidemiology","year":2024,"id":468315,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9262,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1301458,"name":"Zachary D. Shepelak","orcid":null,"position":1,"is_corresponding":false},{"id":495874,"name":"Joseph B. Stanford","orcid":"0000-0002-9932-3947","position":2,"is_corresponding":false},{"id":257473,"name":"Robert M. Silver","orcid":"0000-0002-5794-3152","position":3,"is_corresponding":false},{"id":311701,"name":"Sunni L. Mumford","orcid":"0000-0003-0133-3176","position":4,"is_corresponding":false},{"id":311707,"name":"Enrique F. Schisterman","orcid":"0000-0003-3757-641X","position":5,"is_corresponding":false},{"id":308445,"name":"Stefanie N. Hinkle","orcid":"0000-0003-4312-708X","position":6,"is_corresponding":false},{"id":302604,"name":"Flory L. Nkoy","orcid":"0000-0002-8954-8288","position":7,"is_corresponding":false},{"id":398045,"name":"Lauren H. Theilen","orcid":"0000-0002-5662-6040","position":8,"is_corresponding":false},{"id":797299,"name":"Jessica Pagé","orcid":"0000-0002-2570-4333","position":9,"is_corresponding":false},{"id":310339,"name":"Jessica G. Woo","orcid":"0000-0003-3644-8432","position":10,"is_corresponding":false},{"id":1100935,"name":"B. H. Brown","orcid":null,"position":11,"is_corresponding":false},{"id":388820,"name":"Michael W. Varner","orcid":"0000-0001-9455-3973","position":12,"is_corresponding":false},{"id":400024,"name":"Karen C. Schliep","orcid":"0000-0003-1771-3157","position":13,"is_corresponding":false},{"id":1103067,"name":"May Shaaban","orcid":"0000-0002-7998-8896","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:05:19.071498Z","pmid":"38886184","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}