{"doi":"10.1111/pim.12764","title":"Human immunoglobulin G responses to <i>Cimex lectularius</i> L. saliva","abstract":"AIMS: To investigate the immunoglobulin (Ig) G response after being fed upon by Cimex lectularius L. METHODS AND RESULTS: Participants were fed upon by three male C lectularius insects weekly for a month. Blood was obtained before the feeding and at the last feeding, which was used for immunoblots against bed bug salivary gland extract, with antihuman Immunoglobulin G (IgG) secondary antibodies. No consistent IgG changes developed in 11 humans serially fed upon by C lectularius. Two participants had new IgG responses to proteins at molecular weights of approximately 12-13 kDa, and one had an IgG response to a protein at approximately 40 kDa. At the last study visit, more intense IgG bands to proteins at molecular weights of 12-13 kDa had developed in 55% of participants (6/11) and at molecular weights of ≈30, ≈40 and ≈70 kDa in 45% (5/11) compared with the first study visit. Nitrophorin and apyrase were the most common C lectularius proteins identified with liquid chromatography-tandem mass spectrometry in both crushed bed bug salivary gland extract and post-bed bug feeding extract. CONCLUSIONS: Human participants did not have consistent IgG responses to crushed C lectularius salivary gland extract.","journal":"Parasite Immunology","year":2020,"id":113657,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9657,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":537014,"name":"Brian Ferrari","orcid":null,"position":1,"is_corresponding":false},{"id":445773,"name":"Jerome Goddard","orcid":"0000-0002-2617-7141","position":2,"is_corresponding":false},{"id":537015,"name":"Danie Schlatzer","orcid":null,"position":3,"is_corresponding":false},{"id":247914,"name":"Kathleen C. Lundberg","orcid":"0000-0002-5703-2543","position":4,"is_corresponding":false},{"id":537016,"name":"Katirina Guinto","orcid":null,"position":5,"is_corresponding":false},{"id":536215,"name":"Monica E. Embers","orcid":"0000-0003-4051-7592","position":6,"is_corresponding":false},{"id":537017,"name":"Andrew B. Young","orcid":null,"position":7,"is_corresponding":false},{"id":537018,"name":"Gale E. Ridge","orcid":null,"position":8,"is_corresponding":false},{"id":48337,"name":"Giovanni Damiani","orcid":"0000-0002-2390-6505","position":9,"is_corresponding":false},{"id":376945,"name":"Thomas S. McCormick","orcid":"0000-0002-3294-0326","position":10,"is_corresponding":false},{"id":536214,"name":"Johnathan M. Sheele","orcid":"0000-0003-4503-8590","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T23:13:25.964732Z","pmid":"32516446","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}