{"doi":"10.1111/phpp.70014","title":"Ambient Solar Radiation Predicts Psoriasis Treatment Intensity","abstract":"Observations of seasonal variation in psoriasis severity (worsening in winter and improving in summer) suggest a beneficial effect of ambient solar radiation [1, 2]. Additionally, “climate therapy” using intentional sunlight exposure reduces psoriasis severity [3]. Interestingly, an analysis of psoriasis clinical trial participants by Okun and Okun [4] found no relationship between psoriasis severity and the ambient ultraviolet radiation at investigator sites. Also, Jacobson et al. [5] compared the psoriasis prevalence in extant studies by the mean country latitude and found no substantial correlation. Using a diverse sample of the United States, our study assessed the association of annual local solar radiation with psoriasis treatment intensity. We analyzed de-identified participant data from the National Institutes of Health's All of Us Research Program version 7, which includes data from 2017 to 2022. Seven thousand seven hundred forty eight participants with a diagnosis of psoriasis were identified. To reduce the likelihood of patients requiring systemic immunosuppressive treatments for other conditions, we excluded participants with diagnoses of psoriatic arthritis, rheumatoid arthritis, systemic lupus erythematosus, atopic dermatitis, uveitis, Crohn's disease, and ulcerative colitis. Our final cohort included 5179 participants after excluding participants with missing values for 3-digit ZIP code or body mass index (BMI) as obtained from the participant's electronic health record. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidelines. Treatment intensity was assessed by the presence or absence of a systemic psoriasis treatment or phototherapy (Table S1). Mean annual global horizontal irradiance (GHI) data (1998–2016) for the contiguous United States by ZIP code was obtained from the National Renewable Energy Laboratory [6]. Deprivation index (a composite score calculated by the All of Us Program using measures of poverty, education, housing, and lack of health insurance at the census tract level) was included to control for confounding related to differences in access to care. Descriptive statistics of mean and standard deviation or frequency and percent were calculated. GHI was divided into quartiles: under 3.97 kWh/m2/day (Quartile 1, e.g. Seattle, Washington), 3.97 to 4.05 (Quartile 2, e.g. Chicago, Illinois), 4.05 to 4.92 (Quartile 3, e.g. Atlanta, Georgia), and over 4.92 (Quartile 4, e.g. Los Angeles, California). Multivariable logistic regression compared treatment odds by participant ZIP code GHI, adjusting for deprivation index, age, BMI, sex assigned at birth (hereafter “sex”), race, and ethnicity. Significance was set at two-tailed p < 0.05, and analysis was performed using SAS Studio in the All of Us Researcher Workbench. Of the 5179 participants with psoriasis in the study, 1028 received systemic treatment or phototherapy (Table 1). Lower GHI of the participants' ZIP code was associated with higher odds of receiving systemic treatment or phototherapy (Figure 1). Obesity and female sex were also associated with higher odds of systemic treatment or phototherapy. Age over 75 was associated with lower odds of systemic therapy or phototherapy. We did not find an association between deprivation index, race, or ethnicity and treatment intensity. Our study shows that lower levels of ambient solar radiation are associated with higher odds of receiving systemic therapy or phototherapy for psoriasis, with these treatments serving as possible indicators of more severe disease. The lack of association between severity and ultraviolet radiation seen by Okun and Okun [4] may have been due to clinical trial participants having stable moderate-to-severe psoriasis and being instructed to limit their environmental ultraviolet radiation exposure. Of note, the study by Jacobson et al. [5] of latitude and psoriasis prevalence excluded the United States and China ","journal":"Photodermatology Photoimmunology & Photomedicine","year":2025,"id":563471,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1410204,"name":"Alan B. Fleischer","orcid":"0000-0001-8679-3352","position":1,"is_corresponding":false},{"id":1410203,"name":"Brad R. Woodie","orcid":"0000-0002-7481-5216","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T02:56:13.374766Z","pmid":"40156101","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}