{"doi":"10.1111/php.70058","title":"Possible involvement of keratinocyte‐derived microvesicle particles in human photosensitivity disorders","abstract":"Previous murine studies have implicated acid sphingomyelinase (aSMase)-generated subcellular microvesicle particles (MVP) in photosensitivity. Objective: The current double-blinded placebo-controlled studies examined if a single localized ultraviolet B radiation (UVB) treatment generated more MVP in human subjects with self-identified photosensitivity versus normal controls. A topical 4% formulation of the aSMase inhibitor imipramine applied immediately after UVB blocked the MVP release and erythema responses. Erythema responses at 24 and 72 h in response to multiple UVB fluences and minimal erythema doses (MED) at 24 h and effects of imipramine were also tested. Small cohorts of 10 adult self-identified photosensitive subjects and 12 controls were enrolled in these pilot studies which revealed increased levels of skin MVP in UVB-treated photosensitive subjects over controls which correlated with MED values. Moreover, post-UVB application of imipramine blunted UVB-induced MVP responses as well as tended to diminish erythema levels at 4 h but not at 24 or 72 h in photosensitive patients. Though limited by low numbers of self-identified subjects, these pilot studies provide some support for the hypothesis that MVP could be involved in multiple types of human photosensitivity responses and suggest aSMase inhibition as a potential therapeutic strategy.","journal":"Photochemistry and Photobiology","year":2025,"id":535537,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9667,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1383434,"name":"Madison Owens","orcid":null,"position":1,"is_corresponding":false},{"id":381161,"name":"Anita Thyagarajan","orcid":"0009-0002-1967-418X","position":2,"is_corresponding":false},{"id":1078875,"name":"Danielle A. Corbin","orcid":"0000-0002-9107-3517","position":3,"is_corresponding":false},{"id":378478,"name":"Catherine M.T. Sherwin","orcid":"0000-0002-0844-3207","position":4,"is_corresponding":false},{"id":83359,"name":"Jade Bryant","orcid":null,"position":5,"is_corresponding":false},{"id":1019290,"name":"Garrett W. Fisher","orcid":null,"position":6,"is_corresponding":false},{"id":1419618,"name":"Winston Owens","orcid":null,"position":7,"is_corresponding":false},{"id":1419160,"name":"Alycia Ketter","orcid":"0000-0002-1507-8594","position":8,"is_corresponding":false},{"id":1419619,"name":"A. Umerani","orcid":null,"position":9,"is_corresponding":false},{"id":657227,"name":"Craig A. Rohan","orcid":"0000-0002-4268-4311","position":10,"is_corresponding":false},{"id":390936,"name":"Michael G. Kemp","orcid":"0000-0001-8203-0745","position":11,"is_corresponding":false},{"id":1419620,"name":"Robyn K. Crow","orcid":null,"position":12,"is_corresponding":false},{"id":381163,"name":"Jeffrey B. Travers","orcid":"0000-0001-7232-1039","position":13,"is_corresponding":false},{"id":1300015,"name":"Risha Annamraju","orcid":null,"position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41291099","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}