{"doi":"10.1111/petr.14671","title":"Anti‐spike antibody durability after <scp>SARS‐CoV</scp>‐2 vaccination in adolescent solid organ transplant recipients","abstract":"BACKGROUND: Adolescent solid organ transplant recipients (aSOTRs) who received three doses of the COVID-19 mRNA vaccine experience high seroconversion rates and antibody persistence for up to 3 months. Long-term antibody durability beyond this timeframe following three doses of the SARS-CoV-2 mRNA vaccine remains unknown. We describe antibody responses 6 months following the third vaccine dose (D3) of the BNT162b2 mRNA vaccination among aSOTRs. METHODS: Participants in a multi-center, observational cohort who received the third dose of the vaccine were analyzed for antibodies to the SARS-CoV-2 spike protein receptor-binding domain (Roche Elecsys anti-SARS-CoV-2-S positive: ≥0.8, maximum: >2500 U/mL). Samples were collected at 1-, 3-, and 6-months post-D3. Participants were surveyed at each timepoint and at 12-months post-D3. RESULTS: All 34 participants had positive anti-RBD antibody titers 6 months post-D3. Variations in titers occurred between 3 and 6 months post-D3, with 8/28 (29%) having decreased antibody levels at 6 months compared to 3 months and 2/28 (7%) reporting increased titers at 6 months. The remaining 18/28 (64%) had unchanged antibody titers compared to 3-month post-D3 levels. A total of 4/34 (12%) reported breakthrough infection within 6 months and 3/32 (9%) reported infection after 6-12 months following the third dose of the SARS-CoV-2 mRNA vaccine. CONCLUSIONS: The results suggest that antibody durability persists up to 6 months following three doses of the SARS-CoV-2 mRNA in aSOTRs. Demography and transplant characteristics did not differ for those who experienced antibody weaning. Breakthrough infections did occur, reflecting immune-evasive nature of novel variants such as Omicron.","journal":"Pediatric Transplantation","year":2024,"id":475307,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1155965,"name":"Divya Kalluri","orcid":"0000-0001-8118-8591","position":1,"is_corresponding":false},{"id":1156351,"name":"Rivka Abedon","orcid":null,"position":2,"is_corresponding":false},{"id":952427,"name":"Caroline X. Qin","orcid":"0000-0003-3212-3569","position":3,"is_corresponding":false},{"id":501698,"name":"Scott R. Auerbach","orcid":"0000-0002-2341-0913","position":4,"is_corresponding":false},{"id":1155966,"name":"Olga Charnaya","orcid":"0000-0003-1104-2882","position":5,"is_corresponding":false},{"id":368369,"name":"Lara Danziger‐Isakov","orcid":"0000-0002-5691-5221","position":6,"is_corresponding":false},{"id":1155967,"name":"Noelle H. Ebel","orcid":"0000-0003-4494-1729","position":7,"is_corresponding":false},{"id":366956,"name":"Amy G. Feldman","orcid":"0000-0003-4021-5615","position":8,"is_corresponding":false},{"id":1072765,"name":"Evelyn Hsu","orcid":"0000-0003-4359-7102","position":9,"is_corresponding":false},{"id":277489,"name":"Saeed Mohammad","orcid":"0000-0002-2950-2552","position":10,"is_corresponding":false},{"id":277497,"name":"Emily R. Perito","orcid":"0000-0002-2911-9684","position":11,"is_corresponding":false},{"id":1155968,"name":"Ashley M. Thomas","orcid":"0000-0003-0692-5410","position":12,"is_corresponding":false},{"id":626297,"name":"Teresa Po‐Yu Chiang","orcid":"0000-0003-0601-7420","position":13,"is_corresponding":false},{"id":329411,"name":"Jacqueline Garonzik‐Wang","orcid":"0000-0002-2789-7503","position":14,"is_corresponding":false},{"id":257567,"name":"Dorry L. Segev","orcid":"0000-0002-1924-4801","position":15,"is_corresponding":false},{"id":329412,"name":"William A. Werbel","orcid":"0000-0003-2943-5895","position":16,"is_corresponding":false},{"id":286709,"name":"Douglas Mogul","orcid":"0000-0002-6486-3302","position":17,"is_corresponding":false},{"id":1030914,"name":"John McAteer","orcid":"0000-0001-8913-6219","position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-19T02:06:16.992586Z","pmid":"38317335","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}