{"doi":"10.1111/pai.14208","title":"Association of prenatal vitamin E levels with child asthma and wheeze","abstract":"BACKGROUND: We investigated the individual and interaction effects of maternal plasma 𝛂- and ϒ-tocopherol levels (vitamin E isomers) on child asthma and wheeze at age 8-9. METHODS: Mother-child dyads were enrolled between 2006 and 2011 into the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) prenatal cohort. Maternal second-trimester samples were analyzed for tocopherol and lipid concentrations. We assessed child asthma/wheeze using the International Study of Asthma and Allergies in Childhood (ISAAC) and other self-reported Ent wheeze. In multivariable logistic regression analyses, we assessed associations between vitamin E isomers and child asthma/wheeze outcomes (n = 847 mother-child dyads) and tested for prespecified interaction terms. RESULTS: Median cholesterol-corrected tocopherol levels (interquartile range (IQR)) were 5.0 (4.3-5.7) and 0.8 (0.7-0.9) (umol/mmol) for 𝛂- and ϒ-tocopherol, respectively. Associations between 𝛂-tocopherol and asthma outcome variables were inverse but not statistically significant. In contrast, for ϒ-tocopherol, associations were in the positive direction, but also nonsignificant. Interactions analysis between tocopherols did not reach statistical significance for any outcome. Among children of women with a history of asthma, the likelihood of ever asthma in the child appears to be decreasing with increasing maternal 𝛂-tocopherol levels, whereas this trend was not observed among those without a history of asthma (p-interaction = .05). CONCLUSION: We observed no associations for prenatal 𝛂- or ϒ-tocopherol concentrations with child asthma/wheeze. We detected some evidence of effect modification by maternal asthma history in associations between 𝛂-tocopherol and child asthma.","journal":"Pediatric Allergy and Immunology","year":2024,"id":480906,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8867,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":275876,"name":"Tebeb Gebretsadik","orcid":"0000-0003-4548-3010","position":1,"is_corresponding":false},{"id":325487,"name":"Margaret A. Adgent","orcid":"0000-0002-5951-5514","position":2,"is_corresponding":false},{"id":1320313,"name":"Marshae Nickelberry","orcid":"0000-0001-5756-493X","position":3,"is_corresponding":false},{"id":442436,"name":"Paul E. Moore","orcid":"0000-0001-5123-207X","position":4,"is_corresponding":false},{"id":1320314,"name":"Hannah Carlson","orcid":"0000-0003-3695-7624","position":5,"is_corresponding":false},{"id":1320699,"name":"Myron Gross","orcid":null,"position":6,"is_corresponding":false},{"id":352874,"name":"Qi Zhao","orcid":"0000-0002-5079-1803","position":7,"is_corresponding":false},{"id":1320700,"name":"Cecelia S. Alcala","orcid":null,"position":8,"is_corresponding":false},{"id":509693,"name":"Xueying Zhang","orcid":"0000-0003-0806-3324","position":9,"is_corresponding":false},{"id":275836,"name":"Nicole R. Bush","orcid":"0000-0003-0217-9975","position":10,"is_corresponding":false},{"id":275838,"name":"Kaja Z. LeWinn","orcid":"0000-0002-8245-7279","position":11,"is_corresponding":false},{"id":275585,"name":"Rosalind J. Wright","orcid":"0000-0002-4262-2807","position":12,"is_corresponding":false},{"id":325488,"name":"Kecia N. Carroll","orcid":"0000-0002-6646-1374","position":13,"is_corresponding":false},{"id":363787,"name":"Terryl J. Hartman","orcid":"0000-0001-5942-3161","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:07:02.142014Z","pmid":"39087502","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}