{"doi":"10.1111/pai.13704","title":"Infant gut bacterial community composition and food‐related manifestation of atopy in early childhood","abstract":"BACKGROUND: Immunoglobulin E-mediated food allergy (IgE-FA) has emerged as a global public health concern. Immune dysregulation is an underlying mechanism for IgE-FA, caused by \"dysbiosis\" of the early intestinal microbiota. We investigated the association between infant gut bacterial composition and food-related atopy at age 3-5 years using a well-characterized birth cohort. METHODS: The study definition of IgE-FA to egg, milk, or peanut was based on physician panel retrospective review of clinical and questionnaire data collected from birth through age 3-5 years. Using 16S rRNA sequencing, we profiled the bacterial gut microbiota present in stool specimens collected at 1 and 6 months of age. RESULTS: Of 447 infants with data for analysis, 44 (9.8%) met physician panel review criteria for IgE-FA to ≥1 of the three allergens. Among children classified as IgE-FA at 3-5 years, infant stool samples showed significantly less diversity of the gut microbiota compared with the samples of children classified as no IgE-FA at age 3-5 years, especially for milk and peanut (all covariate-adjusted p's for alpha metrics <.007). Testing of individual operational taxonomic units (OTUs) revealed 6-month deficiencies in 31 OTUs for IgE-FA compared with no IgE-FA, mostly in the orders Lactobacillales, Bacteroidales, and Clostridiales. CONCLUSIONS: Variations in gut microbial composition in infant stool were associated with a study definition of IgE-FA at 3-5 years of age. This included evidence of a lack of bacterial diversity, deficiencies in specific OTUs, and delayed microbial maturation. Results support dysbiosis in IgE-FA pathogenesis.","journal":"Pediatric Allergy and Immunology","year":2021,"id":170459,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7928,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334928,"name":"Alexandra R. Sitarik","orcid":"0000-0001-8957-389X","position":1,"is_corresponding":false},{"id":703270,"name":"Haejin Kim","orcid":"0000-0002-6803-5862","position":2,"is_corresponding":false},{"id":231080,"name":"Gary B. Huffnagle","orcid":"0000-0002-4505-9642","position":3,"is_corresponding":false},{"id":233435,"name":"Kei E. Fujimura","orcid":"0000-0002-4196-6018","position":4,"is_corresponding":false},{"id":335852,"name":"Germaine Yong","orcid":null,"position":5,"is_corresponding":false},{"id":306768,"name":"Albert M. Levin","orcid":"0000-0002-6993-1669","position":6,"is_corresponding":false},{"id":306765,"name":"Edward M. Zoratti","orcid":"0000-0002-2626-0682","position":7,"is_corresponding":false},{"id":233436,"name":"Susan V. Lynch","orcid":"0000-0001-5695-7336","position":8,"is_corresponding":false},{"id":306767,"name":"Dennis R. Ownby","orcid":"0000-0003-0944-6466","position":9,"is_corresponding":false},{"id":289672,"name":"Nicholas W. Lukacs","orcid":"0000-0003-2403-6481","position":10,"is_corresponding":false},{"id":309430,"name":"Brent Davidson","orcid":null,"position":11,"is_corresponding":false},{"id":309411,"name":"Charles Barone","orcid":null,"position":12,"is_corresponding":false},{"id":306763,"name":"Christine Cole Johnson","orcid":"0000-0002-6864-6604","position":13,"is_corresponding":false},{"id":677174,"name":"Christine L.M. Joseph","orcid":"0000-0003-0069-4391","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T23:46:24.040760Z","pmid":"34811824","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}