{"doi":"10.1111/pai.13480","title":"Development of nasal allergen challenge with cockroach in children with asthma","abstract":"BACKGROUND: Nasal allergen challenge (NAC) could be a means to assess indication and/or an outcome of allergen-specific therapies, particularly for perennial allergens. NACs are not commonly conducted in children with asthma, and cockroach NACs are not well established. This study's objective was to identify a range of German cockroach extract doses that induce nasal symptoms and to assess the safety of cockroach NAC in children with asthma. METHODS: Ten adults (18-37 years) followed by 25 children (8-14 years) with well-controlled, persistent asthma and cockroach sensitization underwent NAC with diluent followed by up to 8 escalating doses of cockroach extract (0.00381-11.9 µg/mL Bla g 1). NAC outcome was determined by Total Nasal Symptom Score (TNSS) and/or sneeze score. Cockroach allergen-induced T-cell activation and IL-5 production were measured in peripheral blood mononuclear cells. RESULTS: 67% (6/9) of adults and 68% (17/25) of children had a positive NAC at a median response dose of 0.120 µg/mL [IQR 0.0380-0.379 µg/mL] of Bla g 1. Additionally, three children responded to diluent alone and did not receive any cockroach extract. Overall, 32% (11/34) were positive with sneezes alone, 15% (5/34) with TNSS alone, and 21% (7/34) with both criteria. At baseline, NAC responders had higher cockroach-specific IgE (P = .03), lower cockroach-specific IgG/IgE ratios (children, P = .002), and increased cockroach-specific IL-5-producing T lymphocytes (P = .045). The NAC was well tolerated. CONCLUSION: We report the methodology of NAC development for children with persistent asthma and cockroach sensitization. This NAC could be considered a tool to confirm clinically relevant sensitization and to assess responses in therapeutic studies.","journal":"Pediatric Allergy and Immunology","year":2021,"id":185830,"datarank":0.32988014777306324,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.037993625414766176,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.037993625414766176,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":4,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02710136"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":465641,"name":"Michelle L. 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Searing","orcid":null,"position":8,"is_corresponding":false},{"id":55670,"name":"Alessandro Sette","orcid":"0000-0001-7013-2250","position":9,"is_corresponding":false},{"id":743012,"name":"Baomei Shao","orcid":null,"position":10,"is_corresponding":false},{"id":317024,"name":"Stephen J. Teach","orcid":"0000-0001-9870-6519","position":11,"is_corresponding":false},{"id":110411,"name":"James E. Gern","orcid":"0000-0002-6667-4708","position":12,"is_corresponding":false},{"id":110399,"name":"William W. Busse","orcid":"0000-0003-2591-4696","position":13,"is_corresponding":false},{"id":110410,"name":"Alkis Togias","orcid":"0000-0001-9009-5717","position":14,"is_corresponding":false},{"id":110402,"name":"Robert A. Wood","orcid":"0000-0003-3777-802X","position":15,"is_corresponding":false},{"id":317022,"name":"Andrew H. Liu","orcid":"0009-0004-3961-869X","position":16,"is_corresponding":false},{"id":544265,"name":"Amanda K. Rudman Spergel","orcid":"0000-0002-9418-7317","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T23:48:38.805613Z","pmid":"33606312","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}