{"doi":"10.1111/opo.70018","title":"0.01% Atropine for Myopia Prevention in Pre‐myopia (\n                    <scp>AMPP</scp>\n                    study)","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose</jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and safety of 0.01% atropine eye drops in preventing myopia in children with pre‐myopia.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>In this randomised controlled trial (ChiCTR2200055482), children aged 5–12 years with cycloplegic spherical equivalent (SE) between +0.75D and −0.50D were randomised 1:1 to receive either 0.01% atropine (once nightly) or placebo (once nightly). The primary endpoint was the change in SE after 12 months.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      Sixty‐four subjects (48.4% female) completed the 12‐month follow‐up (32 per group, mean age, 7.47 ± 1.72 vs. 7.84 ± 1.32 years). After 12 months, the change in SE was significantly smaller in the 0.01% atropine group than in the placebo group (−0.23 ± 0.50D vs. −0.49 ± 0.42D;\n                      <jats:italic>p</jats:italic>\n                       = 0.03), representing a 53% reduction in myopia progression. No significant intergroup difference was observed in axial length (AL) change (+0.26 ± 0.16 mm vs. +0.32 ± 0.15 mm;\n                      <jats:italic>p</jats:italic>\n                       = 0.13), corresponding to a 19% reduction in AL elongation. The 0.01% atropine group exhibited significantly larger pupil diameters at all time points (all\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05), while safety parameters (e.g., amplitude of accommodation, tear film stability, intraocular pressure) remained comparable between the groups (all\n                      <jats:italic>p</jats:italic>\n                       &gt; 0.05).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>In 5‐ to 12‐year‐old pre‐myopic children, nightly administration of 0.01% atropine eye drops for 1 year was found to delay myopic shift compared with placebo, and no persistent adverse events were observed. Additionally, the atropine group exhibited less axial elongation than the control group, though this difference was not statistically significant.</jats:p>\n                  </jats:sec>","journal":"Ophthalmic and Physiological Optics","year":2025,"id":630774,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1634319,"name":"Hanru Wang","orcid":"0009-0008-4740-6987","position":1,"is_corresponding":false},{"id":1634320,"name":"Bei Du","orcid":null,"position":2,"is_corresponding":false},{"id":1634321,"name":"Ding Han","orcid":null,"position":3,"is_corresponding":false},{"id":1138364,"name":"Lin Liu","orcid":"0000-0003-0830-2639","position":4,"is_corresponding":false},{"id":1220919,"name":"Ziyu Zhang","orcid":"0000-0002-7142-0518","position":5,"is_corresponding":false},{"id":361036,"name":"Shuwei Zhang","orcid":"0000-0002-4634-2650","position":6,"is_corresponding":false},{"id":231062,"name":"Lei Wang","orcid":"0000-0002-0159-1987","position":7,"is_corresponding":false},{"id":87761,"name":"Mengdi Chai","orcid":null,"position":8,"is_corresponding":false},{"id":87768,"name":"Ruihua Wei","orcid":"0000-0002-9708-0355","position":9,"is_corresponding":false},{"id":1520696,"name":"Meinan He","orcid":"0000-0001-7890-7620","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"0.01% Atropine for Myopia Prevention in Pre‐myopia (\n                    <scp>AMPP</scp>\n                    study)","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose</jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and safety of 0.01% atropine eye drops in preventing myopia in children with pre‐myopia.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>In this randomised controlled trial (ChiCTR2200055482), children aged 5–12 years with cycloplegic spherical equivalent (SE) between +0.75D and −0.50D were randomised 1:1 to receive either 0.01% atropine (once nightly) or placebo (once nightly). The primary endpoint was the change in SE after 12 months.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      Sixty‐four subjects (48.4% female) completed the 12‐month follow‐up (32 per group, mean age, 7.47 ± 1.72 vs. 7.84 ± 1.32 years). After 12 months, the change in SE was significantly smaller in the 0.01% atropine group than in the placebo group (−0.23 ± 0.50D vs. −0.49 ± 0.42D;\n                      <jats:italic>p</jats:italic>\n                       = 0.03), representing a 53% reduction in myopia progression. No significant intergroup difference was observed in axial length (AL) change (+0.26 ± 0.16 mm vs. +0.32 ± 0.15 mm;\n                      <jats:italic>p</jats:italic>\n                       = 0.13), corresponding to a 19% reduction in AL elongation. The 0.01% atropine group exhibited significantly larger pupil diameters at all time points (all\n                      <jats:italic>p</jats:italic>\n                       &lt; 0.05), while safety parameters (e.g., amplitude of accommodation, tear film stability, intraocular pressure) remained comparable between the groups (all\n                      <jats:italic>p</jats:italic>\n                       &gt; 0.05).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>In 5‐ to 12‐year‐old pre‐myopic children, nightly administration of 0.01% atropine eye drops for 1 year was found to delay myopic shift compared with placebo, and no persistent adverse events were observed. Additionally, the atropine group exhibited less axial elongation than the control group, though this difference was not statistically significant.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40938247","pmcid":null,"openalex_id":"https://openalex.org/W4414160533","authors":[],"funders":[{"funder_name":"Tianjin Science and Technology Popularization project","grant_id":"23KPHDRC00270","title":null}],"total_grants":1,"fwci":5.1262,"citation_percentile":0.96160343,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":6}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/opo.70018","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/opo.70018","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/opo.70018","host_type":"publisher"},{"url":"https://doi.org/10.1111/opo.70018","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40938247","host_type":"repository"}],"fields_of_study":["Ophthalmology and Visual Impairment Studies","Retinopathy of Prematurity Studies","Corneal surgery and disorders","Humans","Atropine","Child","Female","Myopia","Ophthalmic Solutions","Refraction, Ocular","Male","Child, Preschool","Mydriatics","Double-Blind Method","Follow-Up Studies","Treatment Outcome","Accommodation, Ocular","Disease Progression","Axial Length, Eye","Dose-Response Relationship, Drug"],"mesh_terms":["Accommodation, Ocular","Atropine","Child","Child, Preschool","Dose-Response Relationship, Drug","Double-Blind Method","Female","Follow-Up Studies","Humans","Male","Mydriatics","Myopia","Ophthalmic Solutions","Refraction, Ocular","Treatment Outcome","Disease Progression","Axial Length, Eye"],"keywords":["Atropine","Adverse effect","Significant difference","Eye disease","Parasympatholytic","Refraction","Axial Length","Pre‐myopia"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T22:08:15.173354Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}