{"doi":"10.1111/omi.12361","title":"Electronic cigarette use enriches periodontal pathogens","abstract":"The effect of electronic cigarette (e-cigarette) smoking, especially its long-term impact on oral health, is poorly understood. Here, we conducted a longitudinal clinical study with two study visits, 6 months apart, to investigate the effect of e-cigarette use on the bacterial community structure in the saliva of 101 periodontitis patients. Our data demonstrated that e-cigarette use altered the oral microbiome in periodontitis patients, enriching members of the Filifactor, Treponema, and Fusobacterium taxa. For patients at the same periodontal disease stage, cigarette smokers and e-cigarette smokers shared more similarities in their oral bacterial composition. E-cigarette smoking may have a similar potential as cigarette smoking at altering the bacterial composition of saliva over time, leading to an increase in the relative abundance of periodontal disease-associated pathogens such as Porphyromonas gingivalis and Fusobacterium nucleatum. The correlation analysis showed that certain genera, such as Dialister, Selenomonas, and Leptotrichia in the e-cigarette smoking group, were positively correlated with the levels of proinflammatory cytokines, including IFN-γ, IL-1β, and TNF-α. E-cigarette use was also associated with elevated levels of proinflammatory cytokines such as IFN-γ and TNF-α, which contribute to oral microbiome dysbiosis and advanced disease state.","journal":"Molecular Oral Microbiology","year":2022,"id":242222,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":252446,"name":"Smruti Pushalkar","orcid":"0000-0001-7215-0671","position":1,"is_corresponding":false},{"id":746926,"name":"Ziyan Lin","orcid":"0000-0002-2508-6985","position":2,"is_corresponding":false},{"id":72291,"name":"Scott C. Thomas","orcid":"0000-0001-5140-6033","position":3,"is_corresponding":false},{"id":873255,"name":"Julia Kishanie Persaud","orcid":null,"position":4,"is_corresponding":false},{"id":318598,"name":"Maria A. Sierra","orcid":"0000-0003-4115-034X","position":5,"is_corresponding":false},{"id":242442,"name":"Mridula Vardhan","orcid":"0000-0002-2358-2387","position":6,"is_corresponding":false},{"id":674333,"name":"Rebeca Vasconcelos","orcid":"0009-0004-4406-6746","position":7,"is_corresponding":false},{"id":858370,"name":"Adenike Akapo","orcid":null,"position":8,"is_corresponding":false},{"id":242444,"name":"Yuqi Guo","orcid":"0000-0001-6008-7150","position":9,"is_corresponding":false},{"id":253428,"name":"Terry Gordon","orcid":null,"position":10,"is_corresponding":false},{"id":253429,"name":"Patricia Corby","orcid":null,"position":11,"is_corresponding":false},{"id":252453,"name":"Angela R. Kamer","orcid":"0000-0003-4299-8238","position":12,"is_corresponding":false},{"id":872562,"name":"Xin Li","orcid":"0000-0002-5034-6929","position":13,"is_corresponding":false},{"id":242445,"name":"Deepak Saxena","orcid":"0000-0003-0563-4259","position":14,"is_corresponding":false},{"id":252451,"name":"Fangxi Xu","orcid":"0000-0002-4265-2133","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T00:23:05.485568Z","pmid":"34997976","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}