{"doi":"10.1111/odi.13384","title":"Overactivation of the NF‐κB pathway impairs molar enamel formation","abstract":"OBJECTIVE: Hypohidrotic ectodermal dysplasia (HED) is a hereditary disorder characterized by abnormal structures and functions of the ectoderm-derived organs, including teeth. HED patients exhibit a variety of dental symptoms, such as hypodontia. Although disruption of the EDA/EDAR/EDARADD/NF-κB pathway is known to be responsible for HED, it remains unclear whether this pathway is involved in the process of enamel formation. EXPERIMENTAL SUBJECTS AND METHODS: To address this question, we examined the mice overexpressing Ikkβ (an essential component required for the activation of NF-κB pathway) under the keratin 5 promoter (K5-Ikkβ). RESULTS: Upregulation of the NF-κB pathway was confirmed in the ameloblasts of K5-Ikkβ mice. Premature abrasion was observed in the molars of K5-Ikkβ mice, which was accompanied by less mineralized enamel. However, no significant changes were observed in the enamel thickness and the pattern of enamel rods in K5-Ikkβ mice. Klk4 expression was significantly upregulated in the ameloblasts of K5-Ikkβ mice at the maturation stage, and the expression of its substrate, amelogenin, was remarkably reduced. This suggests that abnormal enamel observed in K5-Ikkβ mice was likely due to the compromised degradation of enamel protein at the maturation stage. CONCLUSION: Therefore, we could conclude that the overactivation of the NF-κB pathway impairs the process of amelogenesis.","journal":"Oral Diseases","year":2020,"id":74413,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":389776,"name":"Maiko Kawasaki","orcid":null,"position":1,"is_corresponding":false},{"id":389103,"name":"Yasuo Miake","orcid":"0000-0002-8282-3478","position":2,"is_corresponding":false},{"id":389104,"name":"Yurie Yamada","orcid":"0000-0002-0515-1807","position":3,"is_corresponding":false},{"id":389105,"name":"James Blackburn","orcid":"0000-0001-5216-8815","position":4,"is_corresponding":false},{"id":389777,"name":"Katsushige Kawasaki","orcid":null,"position":5,"is_corresponding":false},{"id":389778,"name":"Supaluk Trakanant","orcid":null,"position":6,"is_corresponding":false},{"id":389106,"name":"Takahiro Nagai","orcid":"0000-0002-2538-486X","position":7,"is_corresponding":false},{"id":389107,"name":"Jun Nihara","orcid":"0000-0002-4811-3077","position":8,"is_corresponding":false},{"id":389779,"name":"Takehisa Kudo","orcid":null,"position":9,"is_corresponding":false},{"id":389780,"name":"Fumiya Meguro","orcid":null,"position":10,"is_corresponding":false},{"id":389108,"name":"Ruth Schmidt‐Ullrich","orcid":"0000-0002-2472-6530","position":11,"is_corresponding":false},{"id":389781,"name":"Bigang Liu","orcid":null,"position":12,"is_corresponding":false},{"id":389109,"name":"Yinling Hu","orcid":"0000-0002-4795-8537","position":13,"is_corresponding":false},{"id":389110,"name":"Angustias Page","orcid":"0000-0002-0231-8536","position":14,"is_corresponding":false},{"id":389111,"name":"Ángel Ramı́rez","orcid":"0000-0001-7745-5108","position":15,"is_corresponding":false},{"id":238261,"name":"Paul T. Sharpe","orcid":"0000-0003-2116-9561","position":16,"is_corresponding":false},{"id":389112,"name":"Takeyasu Maeda","orcid":"0000-0001-5317-7510","position":17,"is_corresponding":false},{"id":389113,"name":"Ritsuo Takagi","orcid":"0000-0002-8860-1374","position":18,"is_corresponding":false},{"id":389114,"name":"Atsushi Ohazama","orcid":"0000-0002-3496-0347","position":19,"is_corresponding":false},{"id":389102,"name":"Akane Yamada","orcid":"0000-0002-7074-3817","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T21:45:52.171053Z","pmid":"32369672","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}