{"doi":"10.1111/obr.13369","title":"Impact of risk of generalizability biases in adult obesity interventions: A meta‐epidemiological review and meta‐analysis","abstract":"Biases introduced in early-stage studies can lead to inflated early discoveries. The risk of generalizability biases (RGBs) identifies key features of feasibility studies that, when present, lead to reduced impact in a larger trial. This meta-study examined the influence of RGBs in adult obesity interventions. Behavioral interventions with a published feasibility study and a larger scale trial of the same intervention (e.g., pairs) were identified. Each pair was coded for the presence of RGBs. Quantitative outcomes were extracted. Multilevel meta-regression models were used to examine the impact of RGBs on the difference in the effect size (ES, standardized mean difference) from pilot to larger scale trial. A total of 114 pairs, representing 230 studies, were identified. Overall, 75% of the pairs had at least one RGB present. The four most prevalent RGBs were duration (33%), delivery agent (30%), implementation support (23%), and target audience (22%) bias. The largest reductions in the ES were observed in pairs where an RGB was present in the pilot and removed in the larger scale trial (average reduction ES -0.41, range -1.06 to 0.01), compared with pairs without an RGB (average reduction ES -0.15, range -0.18 to -0.14). Eliminating RGBs during early-stage testing may result in improved evidence.","journal":"Obesity Reviews","year":2021,"id":8035,"datarank":0.8079035382724287,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.374347774588004,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.374347774588004,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":6,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0459,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-11-14","fair_score":67.5,"fair_percentile":96.41600703605981,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":15518,"name":"Lauren von Klinggraeff","orcid":"0000-0002-4417-0701","position":1,"is_corresponding":false},{"id":42132,"name":"Sarah Burkart","orcid":"0000-0002-0840-1680","position":2,"is_corresponding":false},{"id":15517,"name":"Alexis Jones","orcid":"0000-0003-2577-3248","position":3,"is_corresponding":false},{"id":148,"name":"John P. 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