{"doi":"10.1111/obr.13317","title":"Weight loss interventions on health‐related quality of life in those with moderate to severe obesity: Findings from an individual patient data meta‐analysis of randomized trials","abstract":"<jats:title>Summary</jats:title><jats:p>The relationship between BMI and health‐related quality of life (HRQoL) critically affects regulatory approval of interventions for weight loss, but evidence of the association is inconsistent. A higher standard of evidence than that available was sought with an IPD meta‐analysis of 10,884 people enrolled in five randomized controlled trials of intentional weight loss interventions. Cross‐sectional and longitudinal associations of BMI and HRQoL were estimated in mixed effects models specifying a latent variable for HRQoL. Spline regressions captured nonlinear associations across the range of BMI. In cross‐sectional spline regressions, BMI was not associated with HRQoL for people with a BMI &lt; 30 kg/m<jats:sup>2</jats:sup> but was for those with a higher BMI. In longitudinal spline regressions, decreases in BMI were positively associated with HRQoL for people with a BMI ≥ 25 kg/m<jats:sup>2</jats:sup>. The impact of change in BMI was larger for people with higher BMIs than for those with BMIs under 30 kg/m<jats:sup>2</jats:sup>. Lower BMI and decreases in BMI were related to higher HRQoL for people living with obesity but not in the population without excess weight. HRQoL gains from weight loss are greater for more severe obesity. Commissioners should use these estimates for future decision making.</jats:p>","journal":"Obesity Reviews","year":2021,"id":611686,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1197461,"name":"Xue W. Mei","orcid":"0000-0002-6279-4884","position":1,"is_corresponding":false},{"id":932966,"name":"Philip Clarke","orcid":"0000-0002-7555-5348","position":2,"is_corresponding":false},{"id":425621,"name":"Paul Aveyard","orcid":"0000-0002-1802-4217","position":3,"is_corresponding":false},{"id":1574466,"name":"Susan A. Jebb","orcid":null,"position":4,"is_corresponding":false},{"id":371067,"name":"John Buckell","orcid":"0000-0002-4157-4217","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Weight loss interventions on health‐related quality of life in those with moderate to severe obesity: Findings from an individual patient data meta‐analysis of randomized trials","abstract":"<jats:title>Summary</jats:title><jats:p>The relationship between BMI and health‐related quality of life (HRQoL) critically affects regulatory approval of interventions for weight loss, but evidence of the association is inconsistent. A higher standard of evidence than that available was sought with an IPD meta‐analysis of 10,884 people enrolled in five randomized controlled trials of intentional weight loss interventions. Cross‐sectional and longitudinal associations of BMI and HRQoL were estimated in mixed effects models specifying a latent variable for HRQoL. Spline regressions captured nonlinear associations across the range of BMI. In cross‐sectional spline regressions, BMI was not associated with HRQoL for people with a BMI &lt; 30 kg/m<jats:sup>2</jats:sup> but was for those with a higher BMI. In longitudinal spline regressions, decreases in BMI were positively associated with HRQoL for people with a BMI ≥ 25 kg/m<jats:sup>2</jats:sup>. The impact of change in BMI was larger for people with higher BMIs than for those with BMIs under 30 kg/m<jats:sup>2</jats:sup>. Lower BMI and decreases in BMI were related to higher HRQoL for people living with obesity but not in the population without excess weight. HRQoL gains from weight loss are greater for more severe obesity. Commissioners should use these estimates for future decision making.</jats:p>","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34374197","pmcid":null,"openalex_id":"https://openalex.org/W3188379345","authors":[],"funders":[],"total_grants":0,"fwci":4.0512,"citation_percentile":0.94917673,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":10},{"year":2024,"count":7},{"year":2025,"count":11},{"year":2026,"count":5}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/obr.13317","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/obr.13317","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/obr.13317","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/obr.13317","host_type":"publisher"},{"url":"https://doi.org/10.1111/obr.13317","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34374197","host_type":"repository"},{"url":"http://hdl.handle.net/11343/289572","host_type":"repository"},{"url":"https://ora.ox.ac.uk/objects/uuid:5370b0a9-4c85-4c20-b044-8dd44bdafac1","host_type":"repository"}],"fields_of_study":["Bariatric Surgery and Outcomes","Obesity and Health Practices","Obesity, Physical Activity, Diet","Cross-Sectional Studies","Humans","Obesity, Morbid","Quality of Life","Randomized Controlled Trials as Topic","Weight Loss"],"mesh_terms":["Cross-Sectional Studies","Humans","Obesity, Morbid","Quality of Life","Weight Loss","Randomized Controlled Trials as Topic"],"keywords":["Medicine","Obesity","Psychological intervention","Body mass index","Meta-analysis","Weight loss","Quality of life (healthcare)","Gerontology","Health Survey for England","Randomized controlled trial","Demography","Population","Environmental health","Internal medicine","Psychiatry","Commissioning","Health-related Quality Of Life","Ipd Meta-analysis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T21:49:15.713337Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}