{"doi":"10.1111/nyas.14293","title":"Deletion of <i>Wnt5a</i> in osteoclasts results in bone loss through decreased bone formation","abstract":"Bone remodeling is achieved through the coupled activities of osteoclasts and osteoblasts that are controlled by many locally generated secreted factors, including WNT5A. While previous studies have demonstrated that osteoblast-derived WNT5A promotes osteoclastogenesis, the function of osteoclast-derived WNT5A on bone remodeling has remained unexplored. We examined the effects of osteoclast-derived WNT5A on bone homeostasis by utilizing the Cathepsin K-Cre (Ctsk-Cre) mouse to conditionally delete Wnt5a in mature osteoclasts. These mice exhibited reduced trabecular and cortical bone. The low bone-mass phenotype was driven by decreased bone formation, not osteoclast-mediated bone resorption, as osteoclast number and serum CTX marker were unchanged. Furthermore, molecular analysis of osteoclast- and osteoblast-derived WNT5A identified a serine-phosphorylated WNT5A that is unique to RANKL-treated macrophages mimicking osteoclasts. This study suggests a new paradigm in which WNT5A has opposing effects on bone remodeling that are dependent on the cell of origin, an effect that may result from cell type-specific differential posttranslational modifications of WNT5A.","journal":"Annals of the New York Academy of Sciences","year":2020,"id":98923,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":354742,"name":"Guanglu Liu","orcid":null,"position":1,"is_corresponding":false},{"id":487292,"name":"David N. Paglia","orcid":"0000-0002-6079-4629","position":2,"is_corresponding":false},{"id":487293,"name":"Christopher W. Kinter","orcid":"0000-0002-5417-1185","position":3,"is_corresponding":false},{"id":309037,"name":"Lorenzo M. Fernandes","orcid":"0000-0001-5116-170X","position":4,"is_corresponding":false},{"id":487294,"name":"Joseph Lorenzo","orcid":"0000-0003-0610-0216","position":5,"is_corresponding":false},{"id":487822,"name":"Marc F. Hansen","orcid":null,"position":6,"is_corresponding":false},{"id":173858,"name":"Abul Arif","orcid":null,"position":7,"is_corresponding":false},{"id":309043,"name":"Hicham Drissi","orcid":"0000-0002-3322-281X","position":8,"is_corresponding":false},{"id":338673,"name":"Joseph L. Roberts","orcid":"0000-0001-6839-1173","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T22:36:58.511143Z","pmid":"31919867","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}