{"doi":"10.1111/nyas.13383","title":"Water channels and barriers formed by claudins","abstract":"<jats:p>Physiological studies in leaky epithelia, like kidney proximal tubules and the small intestine, have documented water transport via both transcellular and paracellular pathways. The discovery of aquaporin water channels provided a molecular basis for transcellular water movement. In contrast, the contribution, or even existence, of a specific paracellular water pathway has been disputed for a long time, until the cation channel–forming tight junction protein claudin‐2 was shown to also permit the paracellular passage of water through its pore. In proximal kidney tubules, claudin‐2–based water transport contributes 23–30% of the total water transport. Other paracellular ion channels (claudin‐10a, ‐10b, and ‐17) proved to be impermeable to water, although their pore size would be sufficient for water molecules to pass. Studies of barrier‐forming claudins, like claudin‐1 and claudin‐3, which tighten the paracellular pathway against ions and larger solutes, indicate that changes in the expression of these sealing claudins do not influence transepithelial water permeability. The present genetic, molecular, computational, and physiological studies are just now beginning to probe the mechanisms and regulation of paracellular permeation.</jats:p>","journal":"Annals of the New York Academy of Sciences","year":2017,"id":42930,"datarank":2.3644191903672365,"base_score":4.31748811353631,"endowment":4.31748811353631,"self_citation_contribution":0.6476232170304466,"citation_network_contribution":1.7167959733367897,"self_endowment_contribution":0.6476232170304466,"citer_contribution":1.7167959733367897,"corpus_percentile":null,"corpus_rank":null,"citation_count":74,"citer_count":68,"citers_with_citation_signal":56,"citers_with_endowment":56,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":204708,"name":"Dorothee Günzel","orcid":"0000-0002-7998-7164","position":1,"is_corresponding":false},{"id":204709,"name":"Dian Theune","orcid":null,"position":2,"is_corresponding":false},{"id":204710,"name":"Carolina Czichos","orcid":null,"position":3,"is_corresponding":false},{"id":204711,"name":"Jörg‐Dieter Schulzke","orcid":null,"position":4,"is_corresponding":false},{"id":204712,"name":"Michael Fromm","orcid":null,"position":5,"is_corresponding":false},{"id":204707,"name":"Rita Rosenthal","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.31748811353631,"endowment":4.31748811353631,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28636801","pmcid":null,"openalex_id":"https://openalex.org/W2707015926","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"FR 652/12‐1","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":2,"fwci":5.494,"citation_percentile":0.96393225,"influential_citations":1,"citation_trend":[{"year":2018,"count":10},{"year":2019,"count":13},{"year":2020,"count":17},{"year":2021,"count":5},{"year":2022,"count":9},{"year":2023,"count":6},{"year":2024,"count":7},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"closed","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnyas.13383","host_type":"publisher"},{"url":"https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/nyas.13383","host_type":"publisher"},{"url":"https://doi.org/10.1111/nyas.13383","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28636801","host_type":"repository"},{"url":"https://dx.doi.org/10.1111/nyas.13383","host_type":""}],"fields_of_study":["Barrier Structure and Function Studies","Gut microbiota and health","Neurological Disease Mechanisms and Treatments","Chemistry","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Aquaporins","Biological Transport","Claudin-2","Claudins","Humans","Kidney Tubules, Proximal","Permeability","Tight Junctions","Water"],"mesh_terms":["Animals","Biological Transport","Humans","Kidney Tubules, Proximal","Permeability","Water","Tight Junctions","Aquaporins","Claudins","Claudin-2"],"keywords":["Paracellular transport","Claudin","Transcellular","Tight junction","Chemistry","Biophysics","Water transport","Aquaporin","Permeability (electromagnetism)","Cell biology","Water flow","Biochemistry","Biology","Membrane","Geology","Claudins","Paracellular Water Transport","Kidney Tubules, Proximal","Animals","Humans","Water","Biological Transport","Claudin-2","Aquaporins","Permeability","Tight Junctions"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T09:03:21.343130Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}