{"doi":"10.1111/nmo.70060","title":"Efficacy of Mediterranean Diet vs. Low‐<scp>FODMAP</scp> Diet in Patients With Nonconstipated Irritable Bowel Syndrome: A Pilot Randomized Controlled Trial","abstract":"INTRODUCTION: Mediterranean diet (MD) has been proposed as a dietary therapy for irritable bowel syndrome (IBS) but its efficacy remains unclear. We compared the efficacy of MD to a diet low in fermentable oligo-, di-, monosaccharides, and polyols (LFD). METHODS: In this pilot-feasibility, randomized controlled trial (RCT), adult patients with diarrhea-predominant IBS (IBS-D) or mixed bowel pattern (IBS-M) were randomized to MD versus LFD for 4 weeks. Meals were provided for both groups (ModifyHealth, GA). Daily variables included abdominal pain intensity (API) and bloating, while IBS symptom severity score (IBS-SSS) and IBS adequate relief (IBS-AR) were scored weekly. The primary endpoint was the proportion of patients with ≥ 30% decrease in API for ≥ 2/4 weeks. RESULTS: Of 26 randomized patients, 20 finished the study (10 per group). Seventy-three percent of the MD group met the primary endpoint compared to 81.8% of the LFD group (p = 1.0). Although not statistically significant, a numerically higher proportion of the LFD group reported adequate relief and met the responder endpoint for IBS-SSS (50-point reduction) compared to the MD group (54.6% vs. 27.3% for IBS-AR and 81.8% vs. 45.5% for IBS-SSS, p = 0.39 and 0.18, respectively). The LFD group also had a significantly greater reduction in IBS-SSS score over the 4-week treatment period compared to the MD group (-105.5 vs. -60, p = 0.02). CONCLUSION: MD provides symptom relief in IBS-D and IBS-M; however, the magnitude of relief was higher with the LFD. Larger diet comparison studies in real-world settings are needed before MD can be routinely recommended to IBS patients. TRIAL REGISTRATION: Clinicaltrials.gov: NCT05807919.","journal":"Neurogastroenterology & Motility","year":2025,"id":512475,"datarank":0.4303332346800062,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.045590831060775654,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.045590831060775654,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":12,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT05807919"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1372629,"name":"Gregory D. Dean","orcid":null,"position":1,"is_corresponding":false},{"id":1372630,"name":"Sofia Iram","orcid":null,"position":2,"is_corresponding":false},{"id":1112067,"name":"Westley Peng","orcid":null,"position":3,"is_corresponding":false},{"id":1372631,"name":"Samuel W. Chey","orcid":null,"position":4,"is_corresponding":false},{"id":426984,"name":"Samara Rifkin","orcid":"0000-0002-6015-7232","position":5,"is_corresponding":false},{"id":1372632,"name":"Christine Lothen‐Kline","orcid":null,"position":6,"is_corresponding":false},{"id":1372633,"name":"Jane Muir","orcid":null,"position":7,"is_corresponding":false},{"id":316664,"name":"Allen Lee","orcid":"0000-0002-4861-7646","position":8,"is_corresponding":false},{"id":1371971,"name":"Shanti Eswaran","orcid":"0000-0002-4660-3670","position":9,"is_corresponding":false},{"id":539208,"name":"William D. Chey","orcid":"0000-0002-4584-4026","position":10,"is_corresponding":false},{"id":654999,"name":"Prashant Singh","orcid":"0000-0002-3796-2372","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T02:48:06.263458Z","pmid":"40273380","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}