{"doi":"10.1111/nmo.14773","title":"Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation","abstract":"BACKGROUND: Chronic constipation (CC) is defined by symptom criteria reflecting heterogenous physiology. However, many patients with CC have significant psychological comorbidities-an alternative definition using a biopsychosocial classification model could be warranted to inform future treatments. We sought to: (1) empirically derive psychological symptom profiles of patients with CC using latent profile analysis and (2) validate these profiles by comparing them on symptom severity, GI-specific anxiety, body mass index (BMI), and anorectal manometry findings. METHODS: = 47). Depression/anxiety symptoms and eating disorder (ED) symptoms (EAT-26) were used as indicators (i.e., variables used to derive profiles) representing unique psychological constructs. Constipation symptoms, GI-specific anxiety, BMI, and anorectal manometry results were used as validators (i.e., variables used to examine the clinical utility of the resulting profiles). KEY RESULTS: A 5-profile solution provided the best statistical fit, comprising the following latent profiles (LPs): LP1 termed \"high dieting, low bulimia;\" LP2 termed \"high ED symptoms;\" LP3 termed \"moderate ED symptoms;\" LP4 termed \"high anxiety and depression, low ED symptoms;\" and LP5 termed \"low psychological symptoms.\" The low psychological symptom profile (61% of the sample) had lower abdominal and overall constipation severity and lower GI-specific anxiety compared to the four profiles characterized by higher psychological symptoms (of any type). Profiles did not significantly differ on BMI or anorectal manometry results. CONCLUSIONS AND INFERENCES: Profiles with high psychological symptoms had increased constipation symptom severity and GI-specific anxiety in adults with CC. Future research should test whether these profiles predict differential treatment outcomes.","journal":"Neurogastroenterology & Motility","year":2024,"id":446433,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9458,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":672945,"name":"Kelly Buchanan","orcid":"0000-0002-7819-0583","position":1,"is_corresponding":false},{"id":1263705,"name":"Jenna Clukey","orcid":null,"position":2,"is_corresponding":false},{"id":502668,"name":"Thomas E. Joiner","orcid":"0000-0001-6798-9085","position":3,"is_corresponding":false},{"id":50970,"name":"Kyle Staller","orcid":"0000-0003-4925-4290","position":4,"is_corresponding":false},{"id":779199,"name":"Helen Burton Murray","orcid":"0000-0003-2059-3256","position":5,"is_corresponding":false},{"id":978168,"name":"Sophie R. Abber","orcid":"0000-0003-3057-6812","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:01:50.465308Z","pmid":"38396355","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}