{"doi":"10.1111/nmo.14376","title":"Effect of liquid and solid test meals on symptoms and gastric myoelectrical activity in patients with gastroparesis and functional dyspepsia","abstract":"BACKGROUND: Patients with gastroparesis (GP) and functional dyspepsia (FD) have similar symptoms, but the pathophysiology of postprandial symptoms remains uncertain. AIMS: To compare symptoms and gastric myoelectrical activity (GMA) after liquid and solid test meals in patients with GP and FD. METHODS: Patients enrolled in the Gastroparesis Clinical Research Consortium Registry were studied. Clinical characteristics were measured with standard questionnaires. GP was determined by 4-h solid-phase gastric scintigraphy. GMA was measured using electrogastrography before and after ingestion of a water load or nutrient bar on separate days. Symptoms were measured on visual analog scales. GMA responses to the water load for individual patients were also determined. RESULTS: 284 patients with GP and 113 with FD were identified who ingested both test meals. Patients with GP and FD had similar maximal tolerated volumes of water [mean (SD) 378 (218) ml vs. 402 (226) ml, p = 0.23] and reported similar intensity of fullness, nausea, bloating, and abdominal discomfort after the test meals. Twenty-six percent and 19% of the patients with GP and FD, respectively, ingested subthreshold (<238 ml) volumes of water (p = 0.15). Gastric dysrhythmias were recorded in 66% of the GP and 65% of the FD patients after the water load. Symptoms and GMA were similar in both groups after ingestion of the nutrient bar. CONCLUSION: The similarity in GMA responses and symptoms after ingestion of solid or liquid test meals suggests GP and FD are closely related gastric neuromuscular disorders.","journal":"Neurogastroenterology & Motility","year":2022,"id":255234,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":260252,"name":"Mark L. Van Natta","orcid":"0000-0002-3219-9451","position":1,"is_corresponding":false},{"id":323492,"name":"Henry P. Parkman","orcid":"0000-0003-4904-4891","position":2,"is_corresponding":false},{"id":262792,"name":"Madhusudan Grover","orcid":"0000-0001-5092-0831","position":3,"is_corresponding":false},{"id":323497,"name":"Thomas L. Abell","orcid":"0000-0002-3175-5161","position":4,"is_corresponding":false},{"id":323493,"name":"Richard W. McCallum","orcid":"0000-0002-6652-8049","position":5,"is_corresponding":false},{"id":459788,"name":"Hossam A. Shaltout","orcid":"0000-0001-7948-3815","position":6,"is_corresponding":false},{"id":323496,"name":"Irene Sarosiek","orcid":"0000-0003-1678-7269","position":7,"is_corresponding":false},{"id":305799,"name":"Gianrico Farrugia","orcid":"0000-0003-3473-5235","position":8,"is_corresponding":false},{"id":244953,"name":"Robert J. Shulman","orcid":"0000-0003-2385-0991","position":9,"is_corresponding":false},{"id":260254,"name":"James Tonascia","orcid":"0000-0002-6348-022X","position":10,"is_corresponding":false},{"id":871270,"name":"Laura Miriel","orcid":"0000-0003-2379-765X","position":11,"is_corresponding":false},{"id":324750,"name":"Frank A. Hamilton","orcid":null,"position":12,"is_corresponding":false},{"id":68274,"name":"Pankaj J. Pasricha","orcid":"0000-0002-8727-683X","position":13,"is_corresponding":false},{"id":323495,"name":"Kenneth L. Koch","orcid":"0000-0002-0074-6553","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T00:25:12.987829Z","pmid":"35411675","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}