{"doi":"10.1111/nmo.12425","title":"The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Colonic microbiota digest resistant starches producing short chain fatty acids (<jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s). The main <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s produced are acetate, propionate, and butyrate. Both excitatory and inhibitory effects of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on motility have been reported. We hypothesized that the effect of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on colonic motility varies with chain length and aimed to determine the effects of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on propagating and non‐propagating contractions of guinea pig proximal and distal colon.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In isolated proximal colonic segments, <jats:styled-content style=\"fixed-case\">K</jats:styled-content>rebs solution alone or containing 10–100 mM acetate, propionate, or butyrate was injected into the lumen, motility was videorecorded over 10 min, and spatiotemporal maps created. In distal colon, the lumen was perfused with the same solutions of <jats:styled-content style=\"fixed-case\">SCFAs</jats:styled-content> at 0.1 mL/min, the movement of artificial fecal pellets videorecorded, and velocity of propulsion calculated.</jats:p></jats:sec><jats:sec><jats:title>Key Results</jats:title><jats:p>In proximal colon, butyrate increased the frequency of full‐length propagations, decreased short propagations, and had a biphasic effect on non‐propagating contractions. Propionate blocked full and short propagations and had a biphasic effect on non‐propagating contractions. Acetate decreased short and total propagations. In distal colon, butyrate increased and propionate decreased velocity of propulsion.</jats:p></jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences</jats:title><jats:p>The data suggest that luminal <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s have differing effects on proximal and distal colonic motility depending on chain length. Thus, the net effect of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on colonic motility would depend on the balance of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s produced by microbial digestion of resistant starches.</jats:p></jats:sec>","journal":"Neurogastroenterology &amp; Motility","year":2014,"id":599731,"datarank":0.736898232860408,"base_score":4.912654885736052,"endowment":4.912654885736052,"self_citation_contribution":0.736898232860408,"citation_network_contribution":0.0,"self_endowment_contribution":0.736898232860408,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":135,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1109987,"name":"Derek M. Kendig","orcid":"0000-0002-3594-9916","position":1,"is_corresponding":false},{"id":1537103,"name":"Karnam S. Murthy","orcid":null,"position":2,"is_corresponding":false},{"id":299690,"name":"John R. Grider","orcid":"0000-0002-0268-8772","position":3,"is_corresponding":false},{"id":1537102,"name":"Norm R. Hurst","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Colonic microbiota digest resistant starches producing short chain fatty acids (<jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s). The main <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s produced are acetate, propionate, and butyrate. Both excitatory and inhibitory effects of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on motility have been reported. We hypothesized that the effect of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on colonic motility varies with chain length and aimed to determine the effects of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on propagating and non‐propagating contractions of guinea pig proximal and distal colon.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In isolated proximal colonic segments, <jats:styled-content style=\"fixed-case\">K</jats:styled-content>rebs solution alone or containing 10–100 mM acetate, propionate, or butyrate was injected into the lumen, motility was videorecorded over 10 min, and spatiotemporal maps created. In distal colon, the lumen was perfused with the same solutions of <jats:styled-content style=\"fixed-case\">SCFAs</jats:styled-content> at 0.1 mL/min, the movement of artificial fecal pellets videorecorded, and velocity of propulsion calculated.</jats:p></jats:sec><jats:sec><jats:title>Key Results</jats:title><jats:p>In proximal colon, butyrate increased the frequency of full‐length propagations, decreased short propagations, and had a biphasic effect on non‐propagating contractions. Propionate blocked full and short propagations and had a biphasic effect on non‐propagating contractions. Acetate decreased short and total propagations. In distal colon, butyrate increased and propionate decreased velocity of propulsion.</jats:p></jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences</jats:title><jats:p>The data suggest that luminal <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s have differing effects on proximal and distal colonic motility depending on chain length. Thus, the net effect of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s on colonic motility would depend on the balance of <jats:styled-content style=\"fixed-case\">SCFA</jats:styled-content>s produced by microbial digestion of resistant starches.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":4.912654885736052,"endowment":4.912654885736052,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25223619","pmcid":"PMC4438679","openalex_id":"https://openalex.org/W1971641444","authors":[],"funders":[{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"DK34153","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK15564","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK028300","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"K12 GM093857","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK015564","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK034153","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R56 DK034153","title":null}],"total_grants":7,"fwci":3.3575,"citation_percentile":0.91598361,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":8},{"year":2017,"count":5},{"year":2018,"count":12},{"year":2019,"count":9},{"year":2020,"count":18},{"year":2021,"count":11},{"year":2022,"count":16},{"year":2023,"count":22},{"year":2024,"count":13},{"year":2025,"count":13},{"year":2026,"count":5}],"oa_status":"green","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4438679","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4438679","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnmo.12425","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/nmo.12425","host_type":"publisher"},{"url":"https://doi.org/10.1111/nmo.12425","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25223619","host_type":"repository"}],"fields_of_study":["Gastrointestinal motility and disorders","Gut microbiota and health","Food composition and properties","Animals","Butyrates","Colon","Female","Gastrointestinal Motility","Guinea Pigs","Male","Organ Culture Techniques","Propionates"],"mesh_terms":["Animals","Butyrates","Colon","Female","Gastrointestinal Motility","Guinea Pigs","Male","Organ Culture Techniques","Propionates"],"keywords":["Butyrate","Propionate","Motility","Distal colon","Lumen (anatomy)","Short-chain fatty acid","Large intestine","Chemistry","Small intestine","Internal medicine","Biophysics","Biology","Biochemistry","Endocrinology","Cell biology","Medicine","Gastrointestinal tract","Peristalsis","Intestinal Motility","Spatiotemporal Maps","Colonic Propulsion"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T11:06:32.671492Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}