{"doi":"10.1111/myc.13491","title":"Comparison of features and outcomes between <scp>HIV</scp>‐negative patients with <i>Cryptococcus gattii</i> meningitis and <i>Cryptococcus neoformans</i> meningitis in South China","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>The objective of this study is to compare the epidemiologic, clinical, laboratory, and imaging features, and outcomes in patients with <jats:italic>Cryptococcus gattii</jats:italic> meningitis (CGM) and <jats:italic>Cryptococcus neoformans</jats:italic> meningitis (CNM).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a retrospective study of HIV‐negative patients with CGM and CNM (2015–2021) distinguished by metagenomic next‐generation sequencing in cerebrospinal fluid in South China.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 81 patients (17 CGM, 64 CNM) were enrolled (72.8% male, median age 49 years, range 21–77 years), and CGM patients were younger (median, 43 vs 53 years, <jats:italic>p</jats:italic> = .005). Of 17 CGM, VGI and VGII accounted for 70.6% and 29.4%, respectively. CGM patients had less underlying diseases (7/17 [41.2%] vs 48/64 [75%], <jats:italic>p</jats:italic> = .018) and focal neurologic deficit (3/17 [17.6%] vs 35/64 [54.7%], <jats:italic>p</jats:italic> = .022), had higher intracranial pressure (15/17 [88.2%] vs 25/64 [39.1%], <jats:italic>p</jats:italic> = .002), more meningeal enhancement (14/17 [82.4%] vs 32/64 [50%], <jats:italic>p</jats:italic> = .034), less parenchymal involvement (median, 1 vs 3, <jats:italic>p</jats:italic> = .018), more lung cryptococcomas (6/12 [50%] vs 6/47 [12.8%], <jats:italic>p</jats:italic> = .014), faster CSF fungal clearance (<jats:italic>p</jats:italic> = .004), less complications (median, 1 vs 3, <jats:italic>p</jats:italic> &lt; .001), and more favourable outcomes (16/17 [94.1%] vs 41/64 [64.1%], <jats:italic>p</jats:italic> = .035).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This study demonstrated that species identification helps to guide therapy and predict outcomes.</jats:p></jats:sec>","journal":"Mycoses","year":2022,"id":633857,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1643600,"name":"Wei‐Peng Li","orcid":null,"position":1,"is_corresponding":false},{"id":1643601,"name":"Jun‐Yu Liu","orcid":null,"position":2,"is_corresponding":false},{"id":1643602,"name":"Yi‐Jie Wang","orcid":null,"position":3,"is_corresponding":false},{"id":334282,"name":"Jia Liu","orcid":"0000-0001-9522-6624","position":4,"is_corresponding":false},{"id":1643603,"name":"Xiao‐Feng Xu","orcid":null,"position":5,"is_corresponding":false},{"id":857608,"name":"Lu Yang","orcid":"0000-0001-9144-3234","position":6,"is_corresponding":false},{"id":244648,"name":"Han Xia","orcid":"0000-0002-5179-0255","position":7,"is_corresponding":false},{"id":527384,"name":"Ying Jiang","orcid":"0000-0001-5760-281X","position":8,"is_corresponding":false},{"id":1643604,"name":"Fu‐Hua Peng","orcid":"0000-0001-7500-205X","position":9,"is_corresponding":false},{"id":1643599,"name":"Xiao‐Hong Su","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of features and outcomes between <scp>HIV</scp>‐negative patients with <i>Cryptococcus gattii</i> meningitis and <i>Cryptococcus neoformans</i> meningitis in South China","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>The objective of this study is to compare the epidemiologic, clinical, laboratory, and imaging features, and outcomes in patients with <jats:italic>Cryptococcus gattii</jats:italic> meningitis (CGM) and <jats:italic>Cryptococcus neoformans</jats:italic> meningitis (CNM).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a retrospective study of HIV‐negative patients with CGM and CNM (2015–2021) distinguished by metagenomic next‐generation sequencing in cerebrospinal fluid in South China.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 81 patients (17 CGM, 64 CNM) were enrolled (72.8% male, median age 49 years, range 21–77 years), and CGM patients were younger (median, 43 vs 53 years, <jats:italic>p</jats:italic> = .005). Of 17 CGM, VGI and VGII accounted for 70.6% and 29.4%, respectively. CGM patients had less underlying diseases (7/17 [41.2%] vs 48/64 [75%], <jats:italic>p</jats:italic> = .018) and focal neurologic deficit (3/17 [17.6%] vs 35/64 [54.7%], <jats:italic>p</jats:italic> = .022), had higher intracranial pressure (15/17 [88.2%] vs 25/64 [39.1%], <jats:italic>p</jats:italic> = .002), more meningeal enhancement (14/17 [82.4%] vs 32/64 [50%], <jats:italic>p</jats:italic> = .034), less parenchymal involvement (median, 1 vs 3, <jats:italic>p</jats:italic> = .018), more lung cryptococcomas (6/12 [50%] vs 6/47 [12.8%], <jats:italic>p</jats:italic> = .014), faster CSF fungal clearance (<jats:italic>p</jats:italic> = .004), less complications (median, 1 vs 3, <jats:italic>p</jats:italic> &lt; .001), and more favourable outcomes (16/17 [94.1%] vs 41/64 [64.1%], <jats:italic>p</jats:italic> = .035).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This study demonstrated that species identification helps to guide therapy and predict outcomes.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35793429","pmcid":null,"openalex_id":"https://openalex.org/W4284889290","authors":[],"funders":[{"funder_name":"Guangdong Basic and Applied Basic Research Foundation","grant_id":"2021A1515110231","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82071265","title":null},{"funder_name":"Science and Technology Program of Guangzhou, China","grant_id":"202102010288","title":null}],"total_grants":3,"fwci":0.8804,"citation_percentile":0.72234672,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/myc.13491","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/myc.13491","host_type":"publisher"},{"url":"https://doi.org/10.1111/myc.13491","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35793429","host_type":"repository"}],"fields_of_study":["Fungal Infections and Studies","Infectious Diseases and Tuberculosis","Antifungal resistance and susceptibility","Adult","Aged","Cryptococcosis","Cryptococcus gattii","Cryptococcus neoformans","Female","HIV Infections","Humans","Male","Meningitis, Cryptococcal","Middle Aged","Retrospective Studies","Young Adult"],"mesh_terms":["Adult","Aged","Cryptococcosis","Cryptococcus neoformans","Female","Humans","Male","Middle Aged","Retrospective Studies","HIV Infections","Meningitis, Cryptococcal","Young Adult","Cryptococcus gattii"],"keywords":["Cryptococcus gattii","Cryptococcus neoformans","Cryptococcus","Meningitis","Cryptococcosis","Medicine","Cerebrospinal fluid","Internal medicine","Cryptococcal meningitis","Retrospective cohort study","Viral meningitis","Gastroenterology","Human immunodeficiency virus (HIV)","Immunology","Surgery","Bacterial meningitis","Biology","Microbiology","Viral disease","Imaging","Outcome","Hiv-negative","Metagenomic Next-generation Sequencing"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T12:46:57.215184Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}