{"doi":"10.1111/mpp.13483","title":"Positive roles of the Ca\n                    <sup>2+</sup>\n                    sensors\n                    <scp>GbCML45</scp>\n                    and\n                    <scp>GbCML50</scp>\n                    in improving cotton Verticillium wilt resistance","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    As a universal second messenger, cytosolic calcium (Ca\n                    <jats:sup>2+</jats:sup>\n                    ) functions in multifaceted intracellular processes, including growth, development and responses to biotic/abiotic stresses in plant. The plant‐specific Ca\n                    <jats:sup>2+</jats:sup>\n                    sensors, calmodulin and calmodulin‐like (CML) proteins, function as members of the second‐messenger system to transfer Ca\n                    <jats:sup>2+</jats:sup>\n                    signal into downstream responses. However, the functions of CMLs in the responses of cotton (\n                    <jats:italic>Gossypium</jats:italic>\n                    spp.) after\n                    <jats:italic>Verticillium dahliae</jats:italic>\n                    infection, which causes the serious vascular disease Verticillium wilt, remain elusive. Here, we discovered that the expression level of\n                    <jats:italic>GbCML45</jats:italic>\n                    was promoted after\n                    <jats:italic>V. dahliae</jats:italic>\n                    infection in roots of cotton, suggesting its potential role in Verticillium wilt resistance. We found that knockdown of\n                    <jats:italic>GbCML45</jats:italic>\n                    in cotton plants decreased resistance while overexpression of\n                    <jats:italic>GbCML45</jats:italic>\n                    in\n                    <jats:italic>Arabidopsis thaliana</jats:italic>\n                    plants enhanced resistance to\n                    <jats:italic>V. dahliae</jats:italic>\n                    infection. Furthermore, there was physiological interaction between GbCML45 and its close homologue GbCML50 by using yeast two‐hybrid and bimolecular fluorescence assays, and both proteins enhanced cotton resistance to\n                    <jats:italic>V. dahliae</jats:italic>\n                    infection in a Ca\n                    <jats:sup>2+</jats:sup>\n                    ‐dependent way in a knockdown study. Detailed investigations indicated that several defence‐related pathways, including salicylic acid, ethylene, reactive oxygen species and nitric oxide signalling pathways, as well as accumulations of lignin and callose, are responsible for\n                    <jats:italic>GbCML45</jats:italic>\n                    ‐ and\n                    <jats:italic>GbCML50</jats:italic>\n                    ‐modulated\n                    <jats:italic>V. dahliae</jats:italic>\n                    resistance in cotton. These results collectively indicated that GbCML45 and GbCML50 act as positive regulators to improve cotton Verticillium wilt resistance, providing potential targets for exploitation of improved Verticillium wilt‐tolerant cotton cultivars by genetic engineering and molecular breeding.\n                  </jats:p>","journal":"Molecular Plant Pathology","year":2024,"id":43153,"datarank":0.42469882261455205,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.03995641899532148,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.03995641899532148,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":9,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":205552,"name":"Yuzhe Li","orcid":null,"position":1,"is_corresponding":false},{"id":205553,"name":"Aosong Song","orcid":null,"position":2,"is_corresponding":false},{"id":180215,"name":"Xinying Shi","orcid":null,"position":3,"is_corresponding":false},{"id":205554,"name":"Shanci Hu","orcid":null,"position":4,"is_corresponding":false},{"id":58892,"name":"Shuang Wu","orcid":"0000-0001-5437-2369","position":5,"is_corresponding":false},{"id":205555,"name":"Lili Shao","orcid":null,"position":6,"is_corresponding":false},{"id":205556,"name":"Zongyan Chu","orcid":null,"position":7,"is_corresponding":false},{"id":205557,"name":"Kun Xu","orcid":null,"position":8,"is_corresponding":false},{"id":205558,"name":"Liangliang Li","orcid":null,"position":9,"is_corresponding":false},{"id":205559,"name":"Lam‐Son Phan Tran","orcid":null,"position":10,"is_corresponding":false},{"id":205560,"name":"Weiqiang Li","orcid":"0000-0002-2324-0387","position":11,"is_corresponding":false},{"id":205561,"name":"Yingfan Cai","orcid":"0000-0002-0347-9075","position":12,"is_corresponding":false},{"id":205551,"name":"Feifei Yi","orcid":"0000-0002-2089-0931","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38829344","pmcid":"PMC11146148","openalex_id":"https://openalex.org/W4399302871","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFD1200300","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFD1500500","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32070262","title":null},{"funder_name":"Natural Science Foundation of Henan Province","grant_id":"222300420404","title":null},{"funder_name":"Strategic Priority Research Program of the Chinese Academy of Sciences","grant_id":"XDA28110102","title":null},{"funder_name":"State Key Laboratory of Cotton Bio-breeding and Intergrated Utilization Opon Fund","grant_id":"CB2024A16","title":null}],"total_grants":6,"fwci":5.3903,"citation_percentile":0.95032937,"influential_citations":0,"citation_trend":[{"year":2025,"count":6},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mpp.13483","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mpp.13483","host_type":"GOLD"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mpp.13483","host_type":"publisher"},{"url":"https://bsppjournals.onlinelibrary.wiley.com/doi/pdf/10.1111/mpp.13483","host_type":"publisher"},{"url":"https://doi.org/10.1111/mpp.13483","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38829344","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11146148","host_type":"repository"},{"url":"https://hdl.handle.net/2346/98698","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11146148/pdf/MPP-25-e13483.pdf","host_type":"repository"},{"url":"https://ttu-ir.tdl.org/bitstreams/27e283c1-1d3d-4291-ae7a-65b72319aafd/download","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11146148","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11146148?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Plant Stress Responses and Tolerance","Plant-Microbe Interactions and Immunity","Plant Gene Expression Analysis","Medicine","Agricultural and Food Sciences","Biology","Gossypium","Disease Resistance","Plant Diseases","Plant Proteins","Calcium","Gene Expression Regulation, Plant","Calmodulin","Arabidopsis","Ascomycota","Plants, Genetically Modified","Verticillium","Verticillium dahliae"],"mesh_terms":["Ascomycota","Calcium","Calmodulin","Gossypium","Plant Diseases","Plant Proteins","Arabidopsis","Gene Expression Regulation, Plant","Verticillium","Plants, Genetically Modified","Disease Resistance"],"keywords":["Verticillium dahliae","Verticillium wilt","Biology","Gossypium","Verticillium","Plant disease resistance","Callose","Salicylic acid","Arabidopsis","Arabidopsis thaliana","Botany","Microbiology","Cell biology","Biochemistry","Gene","Cell wall","Hormones","Calmodulin","Cotton","Reactive oxygen species","Verticillium Wilt Resistance"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T18:09:13.509657Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}