{"doi":"10.1111/micc.70032","title":"Observational Study of Sublingual Microcirculation in Patients With Chronic Cardiovascular Disease","abstract":"BACKGROUND: Sublingual video microscopy is increasingly used to study the microcirculation in acute illness. However, the sublingual microcirculation in patients with chronic cardiovascular diseases (CVD) is understudied. Our objective was to quantify sublingual microcirculatory parameters in a large cohort of patients with CVD. METHODS: One hundred and thirteen patients with CVD were enrolled. Incident dark-field handheld video microscopy (IDF-HVM) was used to quantify microvascular flow index (MFI), microvascular heterogeneity index (MHI), proportion of perfused vessels (PPV), perfused vessel density (PVD), and total vessel density (TVD). Data were stratified by age quartiles (20-39, 40-59, 60-79, 80+), cardiovascular comorbidities (hypertension, diabetes, chronic kidney disease, coronary artery disease, heart failure), and systemic hemodynamics (mean arterial pressure and pulse pressure). RESULTS: . Diabetic patients had lower mean MHI (0.10 vs. 0.17; p = 0.046) compared to those without diabetes. There was no difference in sublingual parameters attributable to other CVDs, age, or hemodynamics. CONCLUSION: In patients with stable cardiovascular disease, sublingual microvascular parameters are similar across age, blood pressure, and comorbidity cohorts, with the exception of decreased MHI in diabetic patients.","journal":"Microcirculation","year":2025,"id":547635,"datarank":0.1295883859307724,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.025616308846780587,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.025616308846780587,"corpus_percentile":29.148294267811558,"corpus_rank":9158,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5498,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":4.1667,"fair_percentile":4.891470498318557,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1439983,"name":"James W. Schurr","orcid":"0000-0001-5330-4604","position":1,"is_corresponding":false},{"id":878034,"name":"Fatima M. Talebi","orcid":null,"position":2,"is_corresponding":false},{"id":800069,"name":"Joyce Wald","orcid":"0000-0003-0276-3709","position":3,"is_corresponding":false},{"id":410117,"name":"John C. Greenwood","orcid":"0000-0003-2337-557X","position":4,"is_corresponding":false},{"id":1439982,"name":"Jacob Niculcea","orcid":"0009-0005-4133-0721","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T02:53:41.314800Z","pmid":"41082272","pmcid":"PMC12517397","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":0.0,"fair_a":0.0,"fair_i":0.0,"fair_r":33.3333,"fair_zscore":-1.1986,"fair_rationale":{"fair_score":4.17,"has_llm":true,"taxonomy_version":"fair_taxonomy_v5","dimensions":{"F":{"name":"Findable","score":0.0,"criteria":[{"key":"f_dataset_pid","label":"Persistent identifier for the data","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":"Data Availability Statement The authors have nothing to report.","grounded":true,"rationale":"No persistent identifier for the dataset is given; the only identifiers are for the paper and IRB.","anchors":["RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit","RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier'","FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'"],"scored":true,"signal":null},{"key":"f_repository_named","label":"Named repository","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":"Data Availability Statement The authors have nothing to report.","grounded":true,"rationale":"No repository is named as the holder of the data.","anchors":["RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed (","NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived","NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten"],"scored":true,"signal":null},{"key":"f_data_availability_statement","label":"Data-availability statement","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":"Data Availability Statement The authors have nothing to report.","grounded":true,"rationale":"The statement exists but declares nothing to report, offering no route to the data. 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For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":"Data Availability Statement The authors have nothing to report.","why":"The text gives no followable route to access the data; it states there is nothing to report. [majority verdict 'no' (3/5 passes agreed)]","gain":16.67,"priority":"essential","scored":true},{"key":"r_reuse_license","dimension":"R","label":"Reuse licence","action":"Attach a standard, machine-readable open licence to the deposit — CC0 or CC BY, which is what Horizon Europe and most funders expect — and print the licence identifier in the paper. 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A name is not a link: it cannot be resolved, versioned, or followed by a machine.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No identifier for any external resource (other dataset, database, or code) is provided.","gain":0.0,"priority":"useful","scored":false},{"key":"a_timeline_retention","dimension":"A","label":"Availability timing & retention","action":"State when the data become available AND how long they will be retained — cite the repository's preservation policy. 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A lab website is not an archive: it has no retention commitment and no accession. For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","Remove the precondition or justify it. Release the data at publication with no embargo, no registration wall, and no approval step — NIH's zero-embargo public- access rule (NOT-OD-25-101) has already made 'available at publication' the federal baseline for the article; the data should not lag behind it. For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","Attach a standard, machine-readable open licence to the deposit — CC0 or CC BY, which is what Horizon Europe and most funders expect — and print the licence identifier in the paper. 'Free to use' is not a licence: it grants nothing a reuser's institution can rely on.","Cite the dataset in the reference list like a publication — creator, year, title, repository, DOI/accession — and cite it in-text where it is used. Only a reference- list entry is machine-readable to Crossref/DataCite, and only a citation lets the data earn credit. Cite the clinical / human-subjects repository accession (e.g. from dbGaP or the European Genome-phenome Archive (EGA)) in the reference list."],"model":"deepseek/deepseek-v4-flash","agent_version":"fair_agent_v8","fulltext_source":"epmc_xml"},"fair_model":"deepseek/deepseek-v4-flash","fair_agent_version":"fair_agent_v8","fair_fulltext_source":"epmc_xml","fair_has_llm":true,"fair_computed_at":"2026-07-20T13:48:37.049716Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}