{"doi":"10.1111/micc.12835","title":"Vascular persistence following precision micropuncture","abstract":"OBJECTIVE: The success of engineered tissues continues to be limited by time to vascularization and perfusion. Recently, we described a simple microsurgical approach, termed micropuncture (MP), which could be used to rapidly vascularize an adjacently placed scaffold from the recipient macrovasculature. Here we studied the long-term persistence of the MP-induced microvasculature. METHODS: Segmental 60 μm diameter MPs were created in the recipient rat femoral artery and vein followed by coverage with a simple Type 1 collagen scaffold. The recipient vasculature and scaffold were then wrapped en bloc with a silicone sheet to isolate intrinsic vascularization. Scaffolds were harvested at 28 days post-implantation for detailed analysis, including using a novel artificial intelligence (AI) approach. RESULTS: MP scaffolds demonstrated a sustained increase of vascular density compared to internal non-MP control scaffolds (p < 0.05) secondary to increases in both vessel diameters (p < 0.05) and branch counts (p < 0.05). MP scaffolds also demonstrated statistically significant increases in red blood cell (RBC) perfused lumens. CONCLUSIONS: This study further highlights that the intrinsic MP-induced vasculature continues to persist long-term. Its combination of rapid and stable angiogenesis represents a novel surgical platform for engineered scaffold and graft perfusion.","journal":"Microcirculation","year":2023,"id":366365,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9654,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1123011,"name":"Patrick C. Hancock","orcid":null,"position":1,"is_corresponding":false},{"id":1005737,"name":"Mingjie Sun","orcid":"0000-0001-9122-3987","position":2,"is_corresponding":false},{"id":1123012,"name":"Alexander T. Liu","orcid":null,"position":3,"is_corresponding":false},{"id":1122585,"name":"Sameer Massand","orcid":"0000-0003-1281-1137","position":4,"is_corresponding":false},{"id":1032970,"name":"Jessica El-Mallah","orcid":null,"position":5,"is_corresponding":false},{"id":699828,"name":"Dana Goldenberg","orcid":null,"position":6,"is_corresponding":false},{"id":1122586,"name":"Olivia Waldron","orcid":"0000-0001-6098-3182","position":7,"is_corresponding":false},{"id":764171,"name":"Mary E. Landmesser","orcid":"0000-0003-2880-0942","position":8,"is_corresponding":false},{"id":1122587,"name":"Shailaja Agrawal","orcid":"0000-0001-7672-058X","position":9,"is_corresponding":false},{"id":310964,"name":"Srinivas V. Koduru","orcid":"0000-0001-6827-2908","position":10,"is_corresponding":false},{"id":698987,"name":"Dino J. Ravnic","orcid":"0000-0003-2261-5180","position":11,"is_corresponding":false},{"id":1123010,"name":"Summer N. Horchler","orcid":null,"position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:14:55.198227Z","pmid":"37947797","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}