{"doi":"10.1111/mec.15005","title":"Testing an hypothesis of hybrid zone movement for toads in France","abstract":"<jats:title>Abstract</jats:title><jats:p>Hybrid zone movement may result in substantial unidirectional introgression of selectively neutral material from the local to the advancing species, leaving a genetic footprint. This genetic footprint is represented by a trail of asymmetric tails and displaced cline centres in the wake of the moving hybrid zone. A peak of admixture linkage disequilibrium is predicted to exist ahead of the centre of the moving hybrid zone. We test these predictions of the movement hypothesis in a hybrid zone between common (<jats:italic>Bufo bufo</jats:italic>) and spined toads (<jats:italic>B. spinosus</jats:italic>), using 31 nuclear and one mtDNA SNPs along a transect in the northwest of France. Average effective selection in<jats:italic>Bufo</jats:italic>hybrids is low and clines vary in shape and centre. A weak pattern of asymmetric introgression is inferred from cline discordance of seven nuclear markers. The dominant direction of gene flow is from<jats:italic>B. spinosus</jats:italic>to<jats:italic>B. bufo</jats:italic>and is in support of southward movement of the hybrid zone. Conversely, a peak of admixture linkage disequilibrium north of the hybrid zone suggests northward movement. These contrasting results can be explained by reproductive isolation of the<jats:italic>B. spinosus</jats:italic>and<jats:italic>B. bufo</jats:italic>gene pools at the southern (<jats:italic>B. spinosus</jats:italic>) side of the hybrid zone. The joint occurrence of asymmetric introgression and admixture linkage disequilibrium can also be explained by the combination of low dispersal and random genetic drift due to low effective population sizes.</jats:p>","journal":"Molecular Ecology","year":2019,"id":38811,"datarank":1.0916773361221748,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.5718169507022156,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.5718169507022156,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":20,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":191910,"name":"Roger K. Butlin","orcid":"0000-0003-4736-0954","position":1,"is_corresponding":false},{"id":191911,"name":"Ben Wielstra","orcid":"0000-0002-7112-5965","position":2,"is_corresponding":false},{"id":191912,"name":"Jan W. Arntzen","orcid":"0000-0003-3229-5993","position":3,"is_corresponding":false},{"id":191909,"name":"Isolde van Riemsdijk","orcid":"0000-0001-9739-6512","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30609055","pmcid":null,"openalex_id":"https://openalex.org/W2907740421","authors":[],"funders":[{"funder_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","grant_id":"824.14.014","title":"Does a moving hybrid zone leave a genomic footprint?"},{"funder_name":"H2020 Marie Skłodowska-Curie Actions","grant_id":"655487","title":"Does a moving hybrid zone leave a genomic footprint?"}],"total_grants":2,"fwci":4.498,"citation_percentile":0.9452168,"influential_citations":1,"citation_trend":[{"year":2019,"count":9},{"year":2020,"count":8},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2025,"count":2}],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.15005","host_type":"journal"},{"url":"https://scholarlypublications.universiteitleiden.nl/access/item%3A2908895/view","host_type":"GREEN"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.15005","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.15005","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.15005","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mec.15005","host_type":"publisher"},{"url":"https://doi.org/10.1111/mec.15005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30609055","host_type":"repository"},{"url":"https://hdl.handle.net/1887/71893","host_type":"repository"},{"url":"http://hdl.handle.net/1887/71893","host_type":"repository"},{"url":"https://eprints.whiterose.ac.uk/140740/1/Riemsdijk_et_al-2019-Molecular_Ecology.pdf","host_type":""},{"url":"https://dx.doi.org/10.1111/mec.15005","host_type":""},{"url":"https://eprints.whiterose.ac.uk/id/eprint/140740/","host_type":""},{"url":"http://dx.doi.org/10.1111/mec.15005","host_type":""}],"fields_of_study":["Genetic diversity and population structure","Evolution and Genetic Dynamics","Animal Behavior and Reproduction","Medicine","Biology","0106 biological sciences","01 natural sciences","Animals","Bufo bufo","Cell Nucleus","DNA, Mitochondrial","France","Gene Flow","Genetic Drift","Genetics, Population","Hybridization, Genetic","Linkage Disequilibrium","Microsatellite Repeats"],"mesh_terms":["Animals","Bufo bufo","Cell Nucleus","DNA, Mitochondrial","France","Genetics, Population","Hybridization, Genetic","Linkage Disequilibrium","Microsatellite Repeats","Genetic Drift","Gene Flow"],"keywords":["Hybrid zone","Cline (biology)","Biology","Bufo","Introgression","Genetic drift","Hybrid","Biological dispersal","Ecology","Gene flow","Evolutionary biology","Population","Genetic variation","Genetics","Gene","Botany","Bufo bufo","Bufo Spinosus","Asymmetric Reproductive Isolation","Hybrid Zone Movement","Admixture Linkage Disequilibrium","Cline Coupling","Cell Nucleus","DNA, Mitochondrial","Linkage Disequilibrium","Genetics, Population","Animals","Hybridization, Genetic","France","Microsatellite Repeats"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.5061/dryad.rg18034","title":"Data from: Testing an hypothesis of hybrid zone movement for toads in France","publisher":"Dryad","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-11T06:25:42.546235Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}