{"doi":"10.1111/mec.14966","title":"Multiple forms of selection shape reproductive isolation in a primate hybrid zone","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Speciation occurs when populations diverge and become reproductively isolated from each other. Natural selection is commonly accepted to play a large role in this process, and it has been widely assumed that reproductive isolation often results as a by‐product of divergence driven by adaptation in allopatry. When such populations come into secondary contact, reinforcement can act to strengthen reproductive isolation, but the frequency and importance of this process are still unknown. Here, we explored genomic signatures of selection in allopatry and sympatry for loci associated with reproductive isolation using a natural primate hybrid zone. By analysing reduced‐representation sequencing data, we quantified admixture and population structure across a howler monkey hybrid zone and examined the relationship between locus‐specific differentiation and introgression. We detected extensive admixture that was mostly limited to the narrow contact zone. Loci with reduced introgression into the heterospecific genomic background (the pattern expected for loci associated with reproductive isolation due to selection against hybrids) were significantly more differentiated between allopatric parental populations than loci with neutral and increased introgression, supporting the hypothesis that reproductive isolation is a by‐product of divergence in allopatry. Further, loci with reduced introgression showed greater differentiation in sympatry than in allopatry, suggesting a role for reinforcement. Thus, our results reflect multiple forms of selection that have shaped reproductive isolation in this system. We conclude that reproductive isolation may have initially been driven by divergence in allopatry, but later reinforced by divergent selection in sympatry.</jats:p>","journal":"Molecular Ecology","year":2019,"id":34710,"datarank":1.1511095665821383,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.6015753196626912,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.6015753196626912,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":33,"citers_with_citation_signal":30,"citers_with_endowment":30,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":179338,"name":"Priscilla K. Tucker","orcid":"0000-0002-6610-7172","position":1,"is_corresponding":false},{"id":179339,"name":"Liliana Cortés‐Ortiz","orcid":"0000-0002-1197-6362","position":2,"is_corresponding":false},{"id":179337,"name":"Marcella D. Baiz","orcid":"0000-0002-1629-6737","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30582763","pmcid":"PMC6888905","openalex_id":"https://openalex.org/W2905842181","authors":[],"funders":[{"funder_name":"University of Michigan","grant_id":"T32‐GM07544","title":null},{"funder_name":"Division of Environmental Biology","grant_id":"DEB‐0640519","title":null},{"funder_name":"DEB-Population and Evolutionary Program Cluster","grant_id":"DEB-0640519","title":null},{"funder_name":"BCS-Physical Anthropology","grant_id":"BCS-0962807","title":null},{"funder_name":"University of Michigan Genetics Training Program","grant_id":"T32-GM07544","title":null},{"funder_name":"BCS-Biological Anthropology","grant_id":"BCS-1517701","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007544","title":null},{"funder_name":"University of Michigan","grant_id":"","title":null},{"funder_name":"Block grant, EEB, University of Michigan","grant_id":"","title":null},{"funder_name":"American Society of Mammalogists","grant_id":"","title":null},{"funder_name":"Grant-In-Aid of Research, American Society of Mammalogists","grant_id":"","title":null},{"funder_name":"Grant-In-Aid of Research, American Society of Mammalogists","grant_id":"","title":null},{"funder_name":"Block grant, EEB, University of Michigan","grant_id":"","title":null}],"total_grants":13,"fwci":3.3164,"citation_percentile":0.92171684,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":7},{"year":2021,"count":6},{"year":2022,"count":5},{"year":2023,"count":6},{"year":2024,"count":6},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#am","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.14966","host_type":"journal"},{"url":"https://europepmc.org/articles/pmc6888905?pdf=render","host_type":"GREEN"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.14966","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmec.14966","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/mec.14966","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mec.14966","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1111/mec.14966","host_type":"publisher"},{"url":"https://doi.org/10.1111/mec.14966","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30582763","host_type":"repository"},{"url":"https://hdl.handle.net/2027.42/149206","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6888905","host_type":"repository"}],"fields_of_study":["Wildlife Ecology and Conservation","Primate Behavior and Ecology","Animal Behavior and Reproduction","Biology","Medicine","Animals","Genetic Speciation","Genetics, Population","Genome","Genomics","Hybridization, Genetic","Primates","Reproduction","Reproductive Isolation","Selection, Genetic","Sympatry"],"mesh_terms":["Animals","Genetics, Population","Hybridization, Genetic","Primates","Reproduction","Selection, Genetic","Genome","Genomics","Genetic Speciation","Reproductive Isolation","Sympatry"],"keywords":["Allopatric speciation","Reproductive isolation","Biology","Sympatry","Introgression","Hybrid zone","Evolutionary biology","Incipient speciation","Natural selection","Ecological speciation","Population","Genetics","Sympatric speciation","Gene flow","Genetic variation","Gene","Admixture","speciation","Population Genomics","Alouatta","Genomic Clines"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.5061/dryad.5d4mb06","title":"Data from: Multiple forms of selection shape reproductive isolation in a primate hybrid zone","publisher":"Dryad","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"bioproject"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T19:44:46.246629Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}