{"doi":"10.1111/liv.70368","title":"Multiparametric <scp>MRI</scp> for Diagnosing Clinically Significant Portal Hypertension and Predicting Liver Decompensation","abstract":"BACKGROUND AND AIMS: Clinically significant portal hypertension (CSPH; hepatic venous pressure gradient (HVPG) ≥ 10 mmHg) is a severe complication of chronic liver disease, with increased risk of variceal bleeding and liver decompensation (at HVPG ≥ 12 mmHg). This study evaluated the performance of multiparametric (mp)MRI for diagnosing CSPH and predicting liver decompensation, compared to ultrasound-based shear wave elastography (SWE) and blood tests. METHODS: mapping, gadoxetate-enhanced dynamic contrast-enhanced MRI (DCE-MRI) of the liver and spleen, SWE and blood tests. Statistical analyses included Mann-Whitney U tests, ROC analysis, logistic regression and Cox proportional hazards models. RESULTS: CSPH was present in 13 patients (22%). Several MRI parameters showed high diagnostic performance for CSPH (AUC ≥ 0.8), with spleen stiffness-2D MRE (AUC 0.88, 95% confidence interval (CI) 0.78-0.98) and liver uptake on DCE-MRI (AUC 0.83, 95% CI 0.70-0.96) performing best, while SWE had AUCs of 0.63 (95% CI 0.45-0.81) for liver and 0.67 (95% CI 0.44-0.89) for spleen. Combining spleen stiffness-2D MRE and liver uptake achieved an AUC of 0.93 (95% CI 0.86-1.00) for diagnosing CSPH. For predicting decompensation, spleen stiffness-3D MRE and liver uptake rate had AUCs of 0.83 (95% CI 0.68-0.99) and 0.83 (95% CI 0.70-0.95), respectively, outperforming SWE. CONCLUSIONS: Spleen stiffness measured with MRE combined with gadoxetate liver uptake (measured with DCE-MRI) can diagnose CSPH and predict liver decompensation, with superior performance compared to SWE. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03436550.","journal":"Liver International","year":2025,"id":576052,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9662,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03436550"]},"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":339856,"name":"Octavia Bane","orcid":"0000-0003-1315-5848","position":1,"is_corresponding":false},{"id":1484185,"name":"Enamul Bhuiyan","orcid":"0000-0002-3098-1095","position":2,"is_corresponding":false},{"id":1313185,"name":"Amine Geahchan","orcid":null,"position":3,"is_corresponding":false},{"id":629865,"name":"Emre Altınmakas","orcid":"0000-0002-0727-9230","position":4,"is_corresponding":false},{"id":430270,"name":"Stefanie J. Hectors","orcid":"0000-0001-9457-6606","position":5,"is_corresponding":false},{"id":1224811,"name":"Paul Kennedy","orcid":"0000-0003-4295-3670","position":6,"is_corresponding":false},{"id":1484635,"name":"Ghadi Abboud","orcid":null,"position":7,"is_corresponding":false},{"id":934145,"name":"Swathi Pavuluri","orcid":"0000-0002-2327-6128","position":8,"is_corresponding":false},{"id":275036,"name":"Richard L. Ehman","orcid":"0000-0001-7041-5074","position":9,"is_corresponding":false},{"id":275037,"name":"Meng Yin","orcid":"0000-0001-6778-192X","position":10,"is_corresponding":false},{"id":685251,"name":"Sara Lewis","orcid":"0000-0002-4713-6453","position":11,"is_corresponding":false},{"id":347137,"name":"Meena B. Bansal","orcid":"0000-0002-7501-2191","position":12,"is_corresponding":false},{"id":925882,"name":"A. Fischman","orcid":"0000-0003-4044-5859","position":13,"is_corresponding":false},{"id":231500,"name":"Swan N. Thung","orcid":"0000-0003-4407-2295","position":14,"is_corresponding":false},{"id":287730,"name":"Thomas D. Schiano","orcid":"0000-0003-1878-5101","position":15,"is_corresponding":false},{"id":685250,"name":"Bachir Taouli","orcid":"0000-0001-6409-1333","position":16,"is_corresponding":false},{"id":1224810,"name":"Efe Ozkaya","orcid":"0000-0003-0583-7507","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:57:52.712371Z","pmid":"41014103","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}