{"doi":"10.1111/liv.16242","title":"Liver Injury due to Intravenous Methylprednisolone in the Drug‐Induced Liver Injury Network","abstract":"BACKGROUND AND AIMS: Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network (DILIN). METHODS: DILIN cases with MP as a suspected drug were reviewed. DILIN causality scoring was assigned on a 5-point scale (definite, highly likely, probable, possible, unlikely). All cases with MP causality scores of definite, highly likely or probable were analysed. HLA data from direct sequencing were analysed. RESULTS: Eleven cases of definite, highly likely, or probable MP DILI were identified. The median age was 48 years; 73% were female; median latency to onset was 30 days; 55% were jaundiced; and all had hepatocellular injury with one patient requiring transplantation. Nine of the 11 cases were in patients with multiple sclerosis (MS). Liver biopsies in 7 cases revealed mild acute hepatitis with/without cholestasis. HLA data demonstrated that HLA-DRB1*15:01, the primary HLA class II allele associated with MS was over-represented. HLA-DQB1*06:02-HLA-DQA1*01:02 which is haplotypic with the HLA-DRB1*15 haplotype was more common in the MP DILI cases compared to other DILI controls (p = 0.03) and to DILI controls exposed to MP (p = 0.04). CONCLUSION: MP DILI is characterised by hepatocellular injury, short latency and generally rapid recovery. There was no independent HLA haplotype associated with MP DILI.","journal":"Liver International","year":2025,"id":530195,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9063,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":286134,"name":"Yi‐Ju Li","orcid":"0000-0001-6996-4834","position":1,"is_corresponding":false},{"id":106289,"name":"Elizabeth J. Phillips","orcid":"0000-0002-7623-3383","position":2,"is_corresponding":false},{"id":305211,"name":"Andrew Dellinger","orcid":"0000-0003-1650-4329","position":3,"is_corresponding":false},{"id":376446,"name":"Paul H. Hayashi","orcid":"0000-0002-5371-1020","position":4,"is_corresponding":false},{"id":260247,"name":"Naga Chalasani","orcid":"0000-0003-2359-6030","position":5,"is_corresponding":false},{"id":255436,"name":"Robert J. Fontana","orcid":"0000-0001-9161-5892","position":6,"is_corresponding":false},{"id":225662,"name":"David E. Kleiner","orcid":"0000-0003-3442-4453","position":7,"is_corresponding":false},{"id":286135,"name":"Huiman X. Barnhart","orcid":"0000-0003-0988-3439","position":8,"is_corresponding":false},{"id":287344,"name":"Jay H. Hoofnagle","orcid":null,"position":9,"is_corresponding":false},{"id":306532,"name":"the Drug‐induced Liver Injury Network","orcid":null,"position":10,"is_corresponding":false},{"id":255440,"name":"Jawad Ahmad","orcid":"0000-0003-1384-2349","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:51:05.836974Z","pmid":"39803998","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}